Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model

Erli Zhang,1 Mingquan Li,2 Jianjun Zhao,2 Yuxiang Dong,1 Xueqin Yang,1 Jingbo Huang1 1Department of Traditional Chinese Medicine, The First Bethune Hospital of Jilin University, 2Department of Encephalopathy, The First Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Chan...

Full description

Bibliographic Details
Main Authors: Zhang E, Li M, Zhao J, Dong Y, Yang X, Huang J
Format: Article
Language:English
Published: Dove Medical Press 2016-09-01
Series:Neuropsychiatric Disease and Treatment
Subjects:
Online Access:https://www.dovepress.com/traditional-chinese-medicine-yisui-tongjing-relieved-neural-severity-i-peer-reviewed-article-NDT
id doaj-7673d5a3bbdd42929729e35d5a90458a
record_format Article
spelling doaj-7673d5a3bbdd42929729e35d5a90458a2020-11-24T22:18:43ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212016-09-01Volume 122481248729187Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat modelZhang ELi MZhao JDong YYang XHuang JErli Zhang,1 Mingquan Li,2 Jianjun Zhao,2 Yuxiang Dong,1 Xueqin Yang,1 Jingbo Huang1 1Department of Traditional Chinese Medicine, The First Bethune Hospital of Jilin University, 2Department of Encephalopathy, The First Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, People’s Republic of China Objective: To study the effect of Yisui Tongjing (YSTJ) prescription on motor nerve conduction velocity (MNCV) and microstructure of the sciatic nerve in experimental autoimmune neuritis (EAN) rats, the Guillain–Barré syndrome classic animal models.Materials and methods: In this study, we established an EAN model in Lewis rats by immunization. We evaluated the potential clinical application of a traditional Chinese medicine YSTJ by intragastric administration and compared its effect with immunoglobulin. The sciatic MNCV was measured by electrophysiology experiment. Hematoxylin–eosin staining and transmission electron microscope analysis were used to determine the pathologically morphological changes before and after YSTJ application.Results: We found that application of YSTJ could significantly alleviate the clinical signs in EAN rats. The treatment also increased MNCV in the sciatic nerve compared to that in the untreated nerve. Demyelination in the sciatic nerve in EAN rats was significantly ameliorated, and newly generated myelinated nerve fibers were observed with treatment of high dose of YSTJ.Conclusion: This study showed that the traditional Chinese medicine YSTJ was likely to serve as a therapeutic medicine in autoimmune neuropathies, providing an effective and economic means to the treatment of Guillain–Barré syndrome. Keywords: Yisui Tongjing, experimental autoimmune neuritis, motor nerve conduction velocity, sciatic nerve, demyelinationhttps://www.dovepress.com/traditional-chinese-medicine-yisui-tongjing-relieved-neural-severity-i-peer-reviewed-article-NDTYisui Tongjingexperimental autoimmune neuritismotor nerve conduction velocitysciatic nervedemyelination
collection DOAJ
language English
format Article
sources DOAJ
author Zhang E
Li M
Zhao J
Dong Y
Yang X
Huang J
spellingShingle Zhang E
Li M
Zhao J
Dong Y
Yang X
Huang J
Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model
Neuropsychiatric Disease and Treatment
Yisui Tongjing
experimental autoimmune neuritis
motor nerve conduction velocity
sciatic nerve
demyelination
author_facet Zhang E
Li M
Zhao J
Dong Y
Yang X
Huang J
author_sort Zhang E
title Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model
title_short Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model
title_full Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model
title_fullStr Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model
title_full_unstemmed Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model
title_sort traditional chinese medicine yisui tongjing relieved neural severity in experimental autoimmune neuritis rat model
publisher Dove Medical Press
series Neuropsychiatric Disease and Treatment
issn 1178-2021
publishDate 2016-09-01
description Erli Zhang,1 Mingquan Li,2 Jianjun Zhao,2 Yuxiang Dong,1 Xueqin Yang,1 Jingbo Huang1 1Department of Traditional Chinese Medicine, The First Bethune Hospital of Jilin University, 2Department of Encephalopathy, The First Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, People’s Republic of China Objective: To study the effect of Yisui Tongjing (YSTJ) prescription on motor nerve conduction velocity (MNCV) and microstructure of the sciatic nerve in experimental autoimmune neuritis (EAN) rats, the Guillain–Barré syndrome classic animal models.Materials and methods: In this study, we established an EAN model in Lewis rats by immunization. We evaluated the potential clinical application of a traditional Chinese medicine YSTJ by intragastric administration and compared its effect with immunoglobulin. The sciatic MNCV was measured by electrophysiology experiment. Hematoxylin–eosin staining and transmission electron microscope analysis were used to determine the pathologically morphological changes before and after YSTJ application.Results: We found that application of YSTJ could significantly alleviate the clinical signs in EAN rats. The treatment also increased MNCV in the sciatic nerve compared to that in the untreated nerve. Demyelination in the sciatic nerve in EAN rats was significantly ameliorated, and newly generated myelinated nerve fibers were observed with treatment of high dose of YSTJ.Conclusion: This study showed that the traditional Chinese medicine YSTJ was likely to serve as a therapeutic medicine in autoimmune neuropathies, providing an effective and economic means to the treatment of Guillain–Barré syndrome. Keywords: Yisui Tongjing, experimental autoimmune neuritis, motor nerve conduction velocity, sciatic nerve, demyelination
topic Yisui Tongjing
experimental autoimmune neuritis
motor nerve conduction velocity
sciatic nerve
demyelination
url https://www.dovepress.com/traditional-chinese-medicine-yisui-tongjing-relieved-neural-severity-i-peer-reviewed-article-NDT
work_keys_str_mv AT zhange traditionalchinesemedicineyisuitongjingrelievedneuralseverityinexperimentalautoimmuneneuritisratmodel
AT lim traditionalchinesemedicineyisuitongjingrelievedneuralseverityinexperimentalautoimmuneneuritisratmodel
AT zhaoj traditionalchinesemedicineyisuitongjingrelievedneuralseverityinexperimentalautoimmuneneuritisratmodel
AT dongy traditionalchinesemedicineyisuitongjingrelievedneuralseverityinexperimentalautoimmuneneuritisratmodel
AT yangx traditionalchinesemedicineyisuitongjingrelievedneuralseverityinexperimentalautoimmuneneuritisratmodel
AT huangj traditionalchinesemedicineyisuitongjingrelievedneuralseverityinexperimentalautoimmuneneuritisratmodel
_version_ 1725782005309767680