Synthesis and Anti-Tuberculosis Activity of the Marine Natural Product Caulerpin and Its Analogues

Caulerpin (1a), a bis-indole alkaloid from the marine algal Caulerpa sp., was synthesized in three reaction steps with an overall yield of 11%. The caulerpin analogues (1b–1g) were prepared using the same synthetic pathway with overall yields between 3% and 8%. The key reaction involved a radical...

Full description

Bibliographic Details
Main Authors: Cristina I. Canché Chay, Rocío Gómez Cansino, Clara I. Espitia Pinzón, Rubén O. Torres-Ochoa, Roberto Martínez
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Marine Drugs
Subjects:
Online Access:http://www.mdpi.com/1660-3397/12/4/1757
id doaj-766c9b037f3746499fba44330571438f
record_format Article
spelling doaj-766c9b037f3746499fba44330571438f2020-11-24T20:50:03ZengMDPI AGMarine Drugs1660-33972014-03-011241757177210.3390/md12041757md12041757Synthesis and Anti-Tuberculosis Activity of the Marine Natural Product Caulerpin and Its AnaloguesCristina I. Canché Chay0Rocío Gómez Cansino1Clara I. Espitia Pinzón2Rubén O. Torres-Ochoa3Roberto Martínez4Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Delegación Coyoacán, México D.F. C.P. 04510, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Delegación Coyoacán, México D.F. C.P. 04510, MexicoInstituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Delegación Coyoacán, México D.F. C.P. 04510, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Delegación Coyoacán, México D.F. C.P. 04510, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Delegación Coyoacán, México D.F. C.P. 04510, MexicoCaulerpin (1a), a bis-indole alkaloid from the marine algal Caulerpa sp., was synthesized in three reaction steps with an overall yield of 11%. The caulerpin analogues (1b–1g) were prepared using the same synthetic pathway with overall yields between 3% and 8%. The key reaction involved a radical oxidative aromatic substitution involving xanthate (3) and 3-formylindole compounds (4a–4g). All bis-indole compounds synthesized were evaluated against the Mycobacterium tuberculosis strain H37Rv, and 1a was found to display excellent activity (IC50 0.24 µM).http://www.mdpi.com/1660-3397/12/4/1757synthesiscaulerpinanaloguesanti-tuberculosis activity
collection DOAJ
language English
format Article
sources DOAJ
author Cristina I. Canché Chay
Rocío Gómez Cansino
Clara I. Espitia Pinzón
Rubén O. Torres-Ochoa
Roberto Martínez
spellingShingle Cristina I. Canché Chay
Rocío Gómez Cansino
Clara I. Espitia Pinzón
Rubén O. Torres-Ochoa
Roberto Martínez
Synthesis and Anti-Tuberculosis Activity of the Marine Natural Product Caulerpin and Its Analogues
Marine Drugs
synthesis
caulerpin
analogues
anti-tuberculosis activity
author_facet Cristina I. Canché Chay
Rocío Gómez Cansino
Clara I. Espitia Pinzón
Rubén O. Torres-Ochoa
Roberto Martínez
author_sort Cristina I. Canché Chay
title Synthesis and Anti-Tuberculosis Activity of the Marine Natural Product Caulerpin and Its Analogues
title_short Synthesis and Anti-Tuberculosis Activity of the Marine Natural Product Caulerpin and Its Analogues
title_full Synthesis and Anti-Tuberculosis Activity of the Marine Natural Product Caulerpin and Its Analogues
title_fullStr Synthesis and Anti-Tuberculosis Activity of the Marine Natural Product Caulerpin and Its Analogues
title_full_unstemmed Synthesis and Anti-Tuberculosis Activity of the Marine Natural Product Caulerpin and Its Analogues
title_sort synthesis and anti-tuberculosis activity of the marine natural product caulerpin and its analogues
publisher MDPI AG
series Marine Drugs
issn 1660-3397
publishDate 2014-03-01
description Caulerpin (1a), a bis-indole alkaloid from the marine algal Caulerpa sp., was synthesized in three reaction steps with an overall yield of 11%. The caulerpin analogues (1b–1g) were prepared using the same synthetic pathway with overall yields between 3% and 8%. The key reaction involved a radical oxidative aromatic substitution involving xanthate (3) and 3-formylindole compounds (4a–4g). All bis-indole compounds synthesized were evaluated against the Mycobacterium tuberculosis strain H37Rv, and 1a was found to display excellent activity (IC50 0.24 µM).
topic synthesis
caulerpin
analogues
anti-tuberculosis activity
url http://www.mdpi.com/1660-3397/12/4/1757
work_keys_str_mv AT cristinaicanchechay synthesisandantituberculosisactivityofthemarinenaturalproductcaulerpinanditsanalogues
AT rociogomezcansino synthesisandantituberculosisactivityofthemarinenaturalproductcaulerpinanditsanalogues
AT claraiespitiapinzon synthesisandantituberculosisactivityofthemarinenaturalproductcaulerpinanditsanalogues
AT rubenotorresochoa synthesisandantituberculosisactivityofthemarinenaturalproductcaulerpinanditsanalogues
AT robertomartinez synthesisandantituberculosisactivityofthemarinenaturalproductcaulerpinanditsanalogues
_version_ 1716804914950176768