Lysosomal Membrane Damage in Soluble Aβ-Mediated Cell Death in Alzheimer's Disease

Lysosomal Membrane Damage in Soluble Aβ-Mediated Cell Death in Alzheimer's Disease

Our previous studies suggest that a failure to degrade aggregated Aβ1-42 in late endosomes or secondary lysosomes is a mechanism that contributes to intracellular accumulation in Alzheimer's disease. In this study, we demonstrate that cultured primary neurons are able to internalize soluble Aβ1...

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Bibliographic Details
Main Authors:	Kristen Ditaranto, Tina L. Tekirian, Austin J. Yang
Format:	Article
Language:	English
Published:	Elsevier 2001-02-01
Series:	Neurobiology of Disease
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996100903644

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