Lysosomal Membrane Damage in Soluble Aβ-Mediated Cell Death in Alzheimer's Disease
Our previous studies suggest that a failure to degrade aggregated Aβ1-42 in late endosomes or secondary lysosomes is a mechanism that contributes to intracellular accumulation in Alzheimer's disease. In this study, we demonstrate that cultured primary neurons are able to internalize soluble Aβ1...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2001-02-01
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| Series: | Neurobiology of Disease |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996100903644 |