Mechanism of exercise-induced analgesia: what we can learn from physically active animals

Mechanism of exercise-induced analgesia: what we can learn from physically active animals

Abstract:. Physical activity has become a first-line treatment in rehabilitation settings for individuals with chronic pain. However, research has only recently begun to elucidate the mechanisms of exercise-induced analgesia. Through the study of animal models, exercise has been shown to induce chan...

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Main Authors: Joseph B. Lesnak, Kathleen A. Sluka
Format: Article
Language:English
Published: Wolters Kluwer 2020-10-01
Series:PAIN Reports
Online Access:http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000850
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spelling doaj-7666c534640640d4ac36383f2e5699a82020-11-25T03:53:18ZengWolters KluwerPAIN Reports2471-25312020-10-0155e85010.1097/PR9.0000000000000850202010000-00020Mechanism of exercise-induced analgesia: what we can learn from physically active animalsJoseph B. Lesnak0Kathleen A. Sluka1Department of Physical Therapy and Rehabilitation Sciences, University of Iowa, Iowa City, IA, USADepartment of Physical Therapy and Rehabilitation Sciences, University of Iowa, Iowa City, IA, USAAbstract:. Physical activity has become a first-line treatment in rehabilitation settings for individuals with chronic pain. However, research has only recently begun to elucidate the mechanisms of exercise-induced analgesia. Through the study of animal models, exercise has been shown to induce changes in the brain, spinal cord, immune system, and at the site of injury to prevent and reduce pain. Animal models have also explored beneficial effects of exercise through different modes of exercise including running, swimming, and resistance training. This review will discuss the central and peripheral mechanisms of exercise-induced analgesia through different modes, intensity, and duration of exercise as well as clinical applications of exercise with suggestions for future research directions.http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000850
collection DOAJ
language English
format Article
sources DOAJ
author Joseph B. Lesnak
Kathleen A. Sluka
spellingShingle Joseph B. Lesnak
Kathleen A. Sluka
Mechanism of exercise-induced analgesia: what we can learn from physically active animals
PAIN Reports
author_facet Joseph B. Lesnak
Kathleen A. Sluka
author_sort Joseph B. Lesnak
title Mechanism of exercise-induced analgesia: what we can learn from physically active animals
title_short Mechanism of exercise-induced analgesia: what we can learn from physically active animals
title_full Mechanism of exercise-induced analgesia: what we can learn from physically active animals
title_fullStr Mechanism of exercise-induced analgesia: what we can learn from physically active animals
title_full_unstemmed Mechanism of exercise-induced analgesia: what we can learn from physically active animals
title_sort mechanism of exercise-induced analgesia: what we can learn from physically active animals
publisher Wolters Kluwer
series PAIN Reports
issn 2471-2531
publishDate 2020-10-01
description Abstract:. Physical activity has become a first-line treatment in rehabilitation settings for individuals with chronic pain. However, research has only recently begun to elucidate the mechanisms of exercise-induced analgesia. Through the study of animal models, exercise has been shown to induce changes in the brain, spinal cord, immune system, and at the site of injury to prevent and reduce pain. Animal models have also explored beneficial effects of exercise through different modes of exercise including running, swimming, and resistance training. This review will discuss the central and peripheral mechanisms of exercise-induced analgesia through different modes, intensity, and duration of exercise as well as clinical applications of exercise with suggestions for future research directions.
url http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000850
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AT kathleenasluka mechanismofexerciseinducedanalgesiawhatwecanlearnfromphysicallyactiveanimals
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