Proteinase 3 Interferes With C1q-Mediated Clearance of Apoptotic Cells

Proteinase 3 Interferes With C1q-Mediated Clearance of Apoptotic Cells

Proteinase 3 (PR3) is the autoantigen in granulomatosis with polyangiitis, an autoimmune necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCAs). Moreover, PR3 is a serine protease whose membrane expression can potentiate inflammatory diseases such as ANCA-associated va...

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Bibliographic Details
Main Authors: Pascale Tacnet-Delorme, Julie Gabillet, Simon Chatfield, Nathalie Thieblemont, Philippe Frachet, Véronique Witko-Sarsat
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
proteinase 3
C1q
apoptotic cells
efferocytosis
autoimmunity
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00818/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00818/full

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