AhR Ligands Differentially Regulate miRNA-132 Which Targets HMGB1 and to Control the Differentiation of Tregs and Th-17 Cells During Delayed-Type Hypersensitivity Response

AhR Ligands Differentially Regulate miRNA-132 Which Targets HMGB1 and to Control the Differentiation of Tregs and Th-17 Cells During Delayed-Type Hypersensitivity Response

Aryl hydrocarbon receptor (AhR), is a transcription factor and an environmental sensor that has been shown to regulate T cell differentiation. Interestingly, AhR ligands exert varying effects from suppression to exacerbation of inflammation through induction of Tregs and Th-17 cells, respectively. I...

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Bibliographic Details
Main Authors: Osama A. Abdulla, Wurood Neamah, Muthanna Sultan, Saurabh Chatterjee, Narendra Singh, Mitzi Nagarkatti, Prakash Nagarkatti
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
AhR
miR-132
HMGB1
Foxp3
IL17
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.635903/full

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