Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines

Little is known about the degradation pathway of cyclic imines that are frequently found in bioactive secondary metabolites. Here, the authors found and characterised a copper amine oxidase, HarA that catalyses a ring-opening reaction of cyclic imine in harmaline and oxidative deamination of amines.

Bibliographic Details
Main Authors:	Toshiki Nagakubo, Takuto Kumano, Takehiro Ohta, Yoshiteru Hashimoto, Michihiko Kobayashi
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-08280-w

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spelling	doaj-765881ec59a145a2b90cd6c617ec662b2021-05-11T11:56:51ZengNature Publishing GroupNature Communications2041-17232019-01-0110111210.1038/s41467-018-08280-wCopper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic iminesToshiki Nagakubo0Takuto Kumano1Takehiro Ohta2Yoshiteru Hashimoto3Michihiko Kobayashi4Graduate School of Life and Environmental Sciences, University of TsukubaGraduate School of Life and Environmental Sciences, University of TsukubaGraduate School of Life Science, University of HyogoGraduate School of Life and Environmental Sciences, University of TsukubaGraduate School of Life and Environmental Sciences, University of TsukubaLittle is known about the degradation pathway of cyclic imines that are frequently found in bioactive secondary metabolites. Here, the authors found and characterised a copper amine oxidase, HarA that catalyses a ring-opening reaction of cyclic imine in harmaline and oxidative deamination of amines.https://doi.org/10.1038/s41467-018-08280-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Toshiki Nagakubo Takuto Kumano Takehiro Ohta Yoshiteru Hashimoto Michihiko Kobayashi
spellingShingle	Toshiki Nagakubo Takuto Kumano Takehiro Ohta Yoshiteru Hashimoto Michihiko Kobayashi Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines Nature Communications
author_facet	Toshiki Nagakubo Takuto Kumano Takehiro Ohta Yoshiteru Hashimoto Michihiko Kobayashi
author_sort	Toshiki Nagakubo
title	Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines
title_short	Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines
title_full	Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines
title_fullStr	Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines
title_full_unstemmed	Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines
title_sort	copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-01-01
description	Little is known about the degradation pathway of cyclic imines that are frequently found in bioactive secondary metabolites. Here, the authors found and characterised a copper amine oxidase, HarA that catalyses a ring-opening reaction of cyclic imine in harmaline and oxidative deamination of amines.
url	https://doi.org/10.1038/s41467-018-08280-w
work_keys_str_mv	AT toshikinagakubo copperamineoxidasescatalyzetheoxidativedeaminationandhydrolysisofcyclicimines AT takutokumano copperamineoxidasescatalyzetheoxidativedeaminationandhydrolysisofcyclicimines AT takehiroohta copperamineoxidasescatalyzetheoxidativedeaminationandhydrolysisofcyclicimines AT yoshiteruhashimoto copperamineoxidasescatalyzetheoxidativedeaminationandhydrolysisofcyclicimines AT michihikokobayashi copperamineoxidasescatalyzetheoxidativedeaminationandhydrolysisofcyclicimines
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Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines

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