Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis

Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis

Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic development. Defective neural crest development can...

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Main Authors: Yu Ji, Hongyan Hao, Kurt Reynolds, Moira McMahon, Chengji J. Zhou
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
wnt
neural crest stem cells
neural crest-derived cancer
Online Access:https://www.mdpi.com/2073-4409/8/10/1173
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spelling doaj-7649eb743eef4415b785b4eae76c8b1c2020-11-25T01:42:23ZengMDPI AGCells2073-44092019-09-01810117310.3390/cells8101173cells8101173Wnt Signaling in Neural Crest Ontogenesis and OncogenesisYu Ji0Hongyan Hao1Kurt Reynolds2Moira McMahon3Chengji J. Zhou4Department of Biochemistry and Molecular Medicine & Comprehensive Cancer Center, University of California at Davis, School of Medicine, Sacramento, CA 95817, USAGraduate Program of Biochemistry, Molecular, Cellular and Developmental Biology, University of California, Davis, CA 95616, USADepartment of Biochemistry and Molecular Medicine & Comprehensive Cancer Center, University of California at Davis, School of Medicine, Sacramento, CA 95817, USAInstitute for Pediatric Regenerative Medicine, UC Davis School of Medicine and Shriners Hospitals for Children, Sacramento, CA 95817, USADepartment of Biochemistry and Molecular Medicine & Comprehensive Cancer Center, University of California at Davis, School of Medicine, Sacramento, CA 95817, USANeural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic development. Defective neural crest development can cause severe and common structural birth defects, such as craniofacial anomalies and congenital heart disease. In the early vertebrate embryos, NC cells emerge from the dorsal edge of the neural tube during neurulation and then migrate extensively throughout the anterior-posterior body axis to generate numerous derivatives. Wnt signaling plays essential roles in embryonic development and cancer. This review summarizes current understanding of Wnt signaling in NC cell induction, delamination, migration, multipotency, and fate determination, as well as in NC-derived cancers.https://www.mdpi.com/2073-4409/8/10/1173wntneural crest stem cellsneural crest-derived cancer
collection DOAJ
language English
format Article
sources DOAJ
author Yu Ji
Hongyan Hao
Kurt Reynolds
Moira McMahon
Chengji J. Zhou
spellingShingle Yu Ji
Hongyan Hao
Kurt Reynolds
Moira McMahon
Chengji J. Zhou
Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis
Cells
wnt
neural crest stem cells
neural crest-derived cancer
author_facet Yu Ji
Hongyan Hao
Kurt Reynolds
Moira McMahon
Chengji J. Zhou
author_sort Yu Ji
title Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis
title_short Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis
title_full Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis
title_fullStr Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis
title_full_unstemmed Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis
title_sort wnt signaling in neural crest ontogenesis and oncogenesis
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2019-09-01
description Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic development. Defective neural crest development can cause severe and common structural birth defects, such as craniofacial anomalies and congenital heart disease. In the early vertebrate embryos, NC cells emerge from the dorsal edge of the neural tube during neurulation and then migrate extensively throughout the anterior-posterior body axis to generate numerous derivatives. Wnt signaling plays essential roles in embryonic development and cancer. This review summarizes current understanding of Wnt signaling in NC cell induction, delamination, migration, multipotency, and fate determination, as well as in NC-derived cancers.
topic wnt
neural crest stem cells
neural crest-derived cancer
url https://www.mdpi.com/2073-4409/8/10/1173
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AT hongyanhao wntsignalinginneuralcrestontogenesisandoncogenesis
AT kurtreynolds wntsignalinginneuralcrestontogenesisandoncogenesis
AT moiramcmahon wntsignalinginneuralcrestontogenesisandoncogenesis
AT chengjijzhou wntsignalinginneuralcrestontogenesisandoncogenesis
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