TGFβ/cyclin D1/Smad-mediated inhibition of BMP4 promotes breast cancer stem cell self-renewal activity

TGFβ/cyclin D1/Smad-mediated inhibition of BMP4 promotes breast cancer stem cell self-renewal activity

Abstract Basal-like triple-negative breast cancers (TNBCs) display poor prognosis, have a high risk of tumor recurrence, and exhibit high resistance to drug treatments. The TNBC aggressive features are largely due to the high proportion of cancer stem cells present within these tumors. In this study...

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Bibliographic Details
Main Authors: Gang Yan, Meiou Dai, Chenjing Zhang, Sophie Poulet, Alaa Moamer, Ni Wang, Julien Boudreault, Suhad Ali, Jean-Jacques Lebrun
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-021-00310-5

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