High throughput determination log Po/w/pKa/log Do/w of drugs by combination of UHPLC and CE methods
In 1997 Valkó et al. developed a generic fast gradient HPLC method, based on the calculation of the chromatographic hydrophobicity index (CHI) from the gradient retention times, in order to measure lipophilicity. We have enhanced the correlations between CHI and log Po/w and adapted the rapid gradie...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Association of Physical Chemists (IAPC)
2014-07-01
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| Series: | ADMET and DMPK |
| Online Access: | http://pub.iapchem.org/ojs/index.php/admet/article/view/44 |