Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1

Abstract E74-like ETS transcription factor 5 (ELF5) is involved in a wide spectrum of biological processes, e.g., mammogenesis and tumor progression. We have identified a list of p300-interacting proteins in human breast cancer cells. Among these, ELF5 was found to interact with p300 via acetylation...

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Bibliographic Details
Main Authors: Xiahui Li, Shujing Li, Bowen Li, Yanan Li, Sattout Aman, Kangkai Xia, Yuxi Yang, Bashir Ahmad, Huijian Wu
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-021-00158-3