RUNX2 as a promising therapeutic target for malignant tumors

Weizhu Zhao,1,2 Haiying Yang,3 Jie Chai,4 Ligang Xing1 1Department of Radiology, Cancer Hospital Affiliated to Shandong First Medical University, Shandong Cancer Hospital and Institute, Jinan, 250117, People’s Republic of China; 2Department of Oncology, Binzhou People’s Hospital,...

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Main Authors: Zhao W, Yang H, Chai J, Xing L
Format: Article
Language:English
Published: Dove Medical Press 2021-03-01
Series:Cancer Management and Research
Subjects:
Online Access:https://www.dovepress.com/runx2-as-a-promising-therapeutic-target-for-malignant-tumors-peer-reviewed-article-CMAR
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spelling doaj-763ac9ea260f485aa2110a4ac130a9e12021-03-16T22:01:24ZengDove Medical PressCancer Management and Research1179-13222021-03-01Volume 132539254863097RUNX2 as a promising therapeutic target for malignant tumorsZhao WYang HChai JXing LWeizhu Zhao,1,2 Haiying Yang,3 Jie Chai,4 Ligang Xing1 1Department of Radiology, Cancer Hospital Affiliated to Shandong First Medical University, Shandong Cancer Hospital and Institute, Jinan, 250117, People’s Republic of China; 2Department of Oncology, Binzhou People’s Hospital, Binzhou, 256610, People’s Republic of China; 3Department of Nursing, Binzhou People’s Hospital, Binzhou, 256610, People’s Republic of China; 4Department of Gastrointestinal Surgery, Cancer Hospital Affiliated to Shandong First Medical University, Shandong Cancer Hospital and Institute, Jinan, 250117, People’s Republic of ChinaCorrespondence: Jie ChaiDepartment of Gastrointestinal Surgery, Cancer Hospital Affiliated to Shandong First Medical University, Shandong Cancer Hospital and Institute, No. 440, Jiyan Road, Jinan, 250117, People’s Republic of ChinaTel +86 18678867800Email gu421720jing@163.comLigang XingDepartment of Radiology, Cancer Hospital Affiliated to Shandong First Medical University, Shandong Cancer Hospital and Institute, No. 440 Jiyan Road, Jinan, 250117, People’s Republic of ChinaTel +86 15553181309Email xinglg@medmail.com.cnAbstract: The transcription factor runt-related protein 2 (RUNX2) has an important impact on the transformation of bone marrow mesenchymal stem cells to osteoblasts. Further studies have shown that RUNX2 plays a key role in the invasion and metastasis of cancers. RUNX2 is a “key” molecule in the regulatory network comprised of multiple signaling pathways upstream and its target downstream molecules. Due to the complex regulatory mechanisms of RUNX2, the specific mechanism underlying the occurrence, development and prognosis of malignant tumors has not been fully understood. Currently, RUNX2 as a promising therapeutic target for cancers has become a research hotspot. Herein, we reviewed the current literature on the modulatory functions and mechanisms of RUNX2 in the development of malignant tumors, aiming to explore its potential clinical application in the diagnosis, prognosis and treatment of tumors.Keywords: RUNX2, malignant tumor;, research progresshttps://www.dovepress.com/runx2-as-a-promising-therapeutic-target-for-malignant-tumors-peer-reviewed-article-CMARrunx2malignant tumorresearch progress
collection DOAJ
language English
format Article
sources DOAJ
author Zhao W
Yang H
Chai J
Xing L
spellingShingle Zhao W
Yang H
Chai J
Xing L
RUNX2 as a promising therapeutic target for malignant tumors
Cancer Management and Research
runx2
malignant tumor
research progress
author_facet Zhao W
Yang H
Chai J
Xing L
author_sort Zhao W
title RUNX2 as a promising therapeutic target for malignant tumors
title_short RUNX2 as a promising therapeutic target for malignant tumors
title_full RUNX2 as a promising therapeutic target for malignant tumors
title_fullStr RUNX2 as a promising therapeutic target for malignant tumors
title_full_unstemmed RUNX2 as a promising therapeutic target for malignant tumors
title_sort runx2 as a promising therapeutic target for malignant tumors
publisher Dove Medical Press
series Cancer Management and Research
issn 1179-1322
publishDate 2021-03-01
description Weizhu Zhao,1,2 Haiying Yang,3 Jie Chai,4 Ligang Xing1 1Department of Radiology, Cancer Hospital Affiliated to Shandong First Medical University, Shandong Cancer Hospital and Institute, Jinan, 250117, People’s Republic of China; 2Department of Oncology, Binzhou People’s Hospital, Binzhou, 256610, People’s Republic of China; 3Department of Nursing, Binzhou People’s Hospital, Binzhou, 256610, People’s Republic of China; 4Department of Gastrointestinal Surgery, Cancer Hospital Affiliated to Shandong First Medical University, Shandong Cancer Hospital and Institute, Jinan, 250117, People’s Republic of ChinaCorrespondence: Jie ChaiDepartment of Gastrointestinal Surgery, Cancer Hospital Affiliated to Shandong First Medical University, Shandong Cancer Hospital and Institute, No. 440, Jiyan Road, Jinan, 250117, People’s Republic of ChinaTel +86 18678867800Email gu421720jing@163.comLigang XingDepartment of Radiology, Cancer Hospital Affiliated to Shandong First Medical University, Shandong Cancer Hospital and Institute, No. 440 Jiyan Road, Jinan, 250117, People’s Republic of ChinaTel +86 15553181309Email xinglg@medmail.com.cnAbstract: The transcription factor runt-related protein 2 (RUNX2) has an important impact on the transformation of bone marrow mesenchymal stem cells to osteoblasts. Further studies have shown that RUNX2 plays a key role in the invasion and metastasis of cancers. RUNX2 is a “key” molecule in the regulatory network comprised of multiple signaling pathways upstream and its target downstream molecules. Due to the complex regulatory mechanisms of RUNX2, the specific mechanism underlying the occurrence, development and prognosis of malignant tumors has not been fully understood. Currently, RUNX2 as a promising therapeutic target for cancers has become a research hotspot. Herein, we reviewed the current literature on the modulatory functions and mechanisms of RUNX2 in the development of malignant tumors, aiming to explore its potential clinical application in the diagnosis, prognosis and treatment of tumors.Keywords: RUNX2, malignant tumor;, research progress
topic runx2
malignant tumor
research progress
url https://www.dovepress.com/runx2-as-a-promising-therapeutic-target-for-malignant-tumors-peer-reviewed-article-CMAR
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