Chest Deformity and Disability due to Tenofovir-Induced Hypophosphatemic Osteomalacia: Case Report and Call for Improved Global Access to Laboratory Testing

Chest Deformity and Disability due to Tenofovir-Induced Hypophosphatemic Osteomalacia: Case Report and Call for Improved Global Access to Laboratory Testing

Millions of people worldwide take tenofovir disoproxil fumarate (TDF) for the treatment of human immunodeficiency virus (HIV) and/or hepatitis B infection. Although generally safe and well tolerated, clinicians need to be aware that TDF can cause proximal renal tubular dysfunction and loss of bone m...

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Main Authors: Jan Hajek, Simple Ouma, Juliya Hemmett, Rob Starko, Paska Apiyo
Format: Article
Language:English
Published: SAGE Publishing 2017-09-01
Series:Journal of the International Association of Providers of AIDS Care
Online Access:https://doi.org/10.1177/2325957417718624
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spelling doaj-763573b714604baf9fe3cacf5b8682ab2020-11-25T01:20:48ZengSAGE PublishingJournal of the International Association of Providers of AIDS Care2325-95742325-95822017-09-011610.1177/2325957417718624Chest Deformity and Disability due to Tenofovir-Induced Hypophosphatemic Osteomalacia: Case Report and Call for Improved Global Access to Laboratory TestingJan Hajek0Simple Ouma1Juliya Hemmett2Rob Starko3Paska Apiyo4 Department of Medicine, University of British Columbia, Vancouver, Canada Gulu Regional Referral Hospital, Gulu, Uganda Department of Medicine, Western University, London, Canada Royal Columbian Hospital, New Westminster, British Columbia, Canada Gulu Regional Referral Hospital, Gulu, UgandaMillions of people worldwide take tenofovir disoproxil fumarate (TDF) for the treatment of human immunodeficiency virus (HIV) and/or hepatitis B infection. Although generally safe and well tolerated, clinicians need to be aware that TDF can cause proximal renal tubular dysfunction and loss of bone mineral density, especially in patients with concomitant renal disease or other risk factors. We present the case of a patient with chronic HIV infection and urethral stricture who developed TDF-related proximal renal tubular dysfunction with hypophosphatemia and osteomalacia, presenting with bone pains, skeletal deformity, and disability. We review risk factors for TDF-related renal tubular toxicity and recommendations for monitoring creatinine, phosphate, alkaline phosphatase, and urinalysis.https://doi.org/10.1177/2325957417718624
collection DOAJ
language English
format Article
sources DOAJ
author Jan Hajek
Simple Ouma
Juliya Hemmett
Rob Starko
Paska Apiyo
spellingShingle Jan Hajek
Simple Ouma
Juliya Hemmett
Rob Starko
Paska Apiyo
Chest Deformity and Disability due to Tenofovir-Induced Hypophosphatemic Osteomalacia: Case Report and Call for Improved Global Access to Laboratory Testing
Journal of the International Association of Providers of AIDS Care
author_facet Jan Hajek
Simple Ouma
Juliya Hemmett
Rob Starko
Paska Apiyo
author_sort Jan Hajek
title Chest Deformity and Disability due to Tenofovir-Induced Hypophosphatemic Osteomalacia: Case Report and Call for Improved Global Access to Laboratory Testing
title_short Chest Deformity and Disability due to Tenofovir-Induced Hypophosphatemic Osteomalacia: Case Report and Call for Improved Global Access to Laboratory Testing
title_full Chest Deformity and Disability due to Tenofovir-Induced Hypophosphatemic Osteomalacia: Case Report and Call for Improved Global Access to Laboratory Testing
title_fullStr Chest Deformity and Disability due to Tenofovir-Induced Hypophosphatemic Osteomalacia: Case Report and Call for Improved Global Access to Laboratory Testing
title_full_unstemmed Chest Deformity and Disability due to Tenofovir-Induced Hypophosphatemic Osteomalacia: Case Report and Call for Improved Global Access to Laboratory Testing
title_sort chest deformity and disability due to tenofovir-induced hypophosphatemic osteomalacia: case report and call for improved global access to laboratory testing
publisher SAGE Publishing
series Journal of the International Association of Providers of AIDS Care
issn 2325-9574
2325-9582
publishDate 2017-09-01
description Millions of people worldwide take tenofovir disoproxil fumarate (TDF) for the treatment of human immunodeficiency virus (HIV) and/or hepatitis B infection. Although generally safe and well tolerated, clinicians need to be aware that TDF can cause proximal renal tubular dysfunction and loss of bone mineral density, especially in patients with concomitant renal disease or other risk factors. We present the case of a patient with chronic HIV infection and urethral stricture who developed TDF-related proximal renal tubular dysfunction with hypophosphatemia and osteomalacia, presenting with bone pains, skeletal deformity, and disability. We review risk factors for TDF-related renal tubular toxicity and recommendations for monitoring creatinine, phosphate, alkaline phosphatase, and urinalysis.
url https://doi.org/10.1177/2325957417718624
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AT simpleouma chestdeformityanddisabilityduetotenofovirinducedhypophosphatemicosteomalaciacasereportandcallforimprovedglobalaccesstolaboratorytesting
AT juliyahemmett chestdeformityanddisabilityduetotenofovirinducedhypophosphatemicosteomalaciacasereportandcallforimprovedglobalaccesstolaboratorytesting
AT robstarko chestdeformityanddisabilityduetotenofovirinducedhypophosphatemicosteomalaciacasereportandcallforimprovedglobalaccesstolaboratorytesting
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