Imatinib and nilotinib inhibit hematopoietic progenitor cell growth, but do not prevent adhesion, migration and engraftment of human cord blood CD34+ cells.

Imatinib and nilotinib inhibit hematopoietic progenitor cell growth, but do not prevent adhesion, migration and engraftment of human cord blood CD34+ cells.

BACKGROUND: The availability of tyrosine kinase inhibitors (TKIs) has considerably changed the management of Philadelphia chromosome positive leukemia. The BCR-ABL inhibitor imatinib is also known to inhibit the tyrosine kinase of the stem cell factor receptor, c-Kit. Nilotinib is 30 times more pote...

Full description

Bibliographic Details
Main Authors:	Ludovic Belle, France Bruck, Jacques Foguenne, André Gothot, Yves Beguin, Frédéric Baron, Alexandra Briquet
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3527577?pdf=render

Similar Items

The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment
by: Andreas Brown, et al.
Published: (2017-11-01)

Nilotinib after imatinib failure
by: Luca Pezzullo
Published: (2015-10-01)

Modulating hematopoietic progenitor cell engraftment and T cell differentiation : role of conditioning and route of administration
by: Cochonneau, Stéphanie
Published: (2012)

Nilotinib therapy after resistance to imatinib
by: Raffaele Porrini, et al.
Published: (2015-10-01)

BONE MARROW HOMING AND ENGRAFTMENT DEFECTS OF HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELLS
by: Giovanni Caocci, et al.
Published: (2017-04-01)

Engraftment of embryonic stem cell-derived hematopoietic progenitor cells is regulated by natural killer cells
by: Tabayoyong, William Borj
Published: (2011)

Nilotinib efficacy in a patient resistant to imatinib
by: Luigia Luciano
Published: (2015-10-01)

The Role of T Cells in Hematopoietic Stem Cell Engraftment
by: Elizabeth Hexner
Published: (2006-01-01)

Complete molecular response induced by nilotinib in a patient previously treated with imatinib, nilotinib and dasatinib
by: Giuseppe Pietrantuono
Published: (2015-10-01)

Different response to imatinib and nilotinib in relationship with the time of administration
by: Paolo Danise
Published: (2015-10-01)

Nilotinib and Imatinib Utilization in Iran over 14 years
by: Ava Mansouri, et al.
Published: (2020-12-01)

In vitro inhibitory effects of imatinib mesylate on stromal cells and hematopoietic progenitors from bone marrow
by: P.B. Soares, et al.
Published: (2013-01-01)

Patient adherence and persistence with Imatinib, Nilotinib, Dasatinib in clinical practice.
by: Fiorenzo Santoleri, et al.
Published: (2013-01-01)

α-bisabolol is an effective proapoptotic agent against BCR-ABL(+) cells in synergism with Imatinib and Nilotinib.
by: Massimiliano Bonifacio, et al.
Published: (2012-01-01)

Human Cytomegalovirus Infection Suppresses CD34<sup>+</sup> Progenitor Cell Engraftment in Humanized Mice
by: Lindsey B. Crawford, et al.
Published: (2020-04-01)

CD44-mediated hyaluronan binding marks proliferating hematopoietic progenitor cells and promotes bone marrow engraftment.
by: Sally S M Lee-Sayer, et al.
Published: (2018-01-01)

Cord Blood-Derived Hematopoietic Stem/Progenitor Cells: Current Challenges in Engraftment, Infection, and Ex Vivo Expansion
by: Katsuhiro Kita, et al.
Published: (2011-01-01)

Critical early events in hematopoietic cell seeding and engraftment.
by: Jerry Stein, et al.
Published: (2005-12-01)

Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34+ Hematopoietic Stem and Progenitor Cells
by: Kai-Hsin Chang, et al.
Published: (2017-03-01)

Role of CD26/DPPIV in the Homing and Engraftment of Long-Term CD34- Negative Hematopoietic Stem Cells
by: Allehaibi, Hanaa S.
Published: (2021)

Early switch to nilotinib in a case of non-optimal response to imatinib
by: Alessandra Iurlo, et al.
Published: (2015-10-01)

First-line treatment for chronic myeloid leukemia: dasatinib, nilotinib, or imatinib
by: Rafiyath Shamudheen, et al.
Published: (2010-11-01)

Transient loading of CD34+ hematopoietic progenitor cells with polystyrene nanoparticles
by: Deville S, et al.
Published: (2017-01-01)

Nilotinib is more potent than imatinib for treating plexiform neurofibroma in vitro and in vivo.
by: Jiang Wei, et al.
Published: (2014-01-01)

Nilotinib: optimal therapy for patients with chronic myeloid leukemia and resistance or intolerance to imatinib
by: Ronan Swords, et al.
Published: (2009-03-01)

Nilotinib after resistance to imatinib in CML patients with Wolf-Parkinson White syndrome
by: Massimo Breccia
Published: (2015-10-01)

Antitumor effect of the tyrosine kinase inhibitor nilotinib on gastrointestinal stromal tumor (GIST) and imatinib-resistant GIST cells.
by: Hiroyuki Sako, et al.
Published: (2014-01-01)

Successful Peripheral Blood Stem Cells Collection in Imatinib Pretreated and Nilotinib-Treated Chronic Myeloid Leukemia Patient
by: Samuel Vokurka, et al.
Published: (2010-01-01)

Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10).
by: Tong Shen, et al.
Published: (2009-10-01)

F4/80+ Host Macrophages Are a Barrier to Murine Embryonic Stem Cell-Derived Hematopoietic Progenitor Engraftment In Vivo
by: Heather L. Thompson, et al.
Published: (2016-01-01)

Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment
by: Yang Mei, et al.
Published: (2020-06-01)

The in vivo timeline of differentiation of engrafted human neural progenitor cells
by: Stefanie Vogel, et al.
Published: (2019-05-01)

The role of T helper 22 cells during engraftment at hematopoietic stem cell transplantation
by: O. Yucel, et al.
Published: (2020-10-01)

Cross talk with hematopoietic cells regulates the endothelial progenitor cell differentiation of CD34 positive cells.
by: Sang-Mo Kwon, et al.
Published: (2014-01-01)

Limited Impact of Imatinib in a Murine Model of Sclerodermatous Chronic Graft-versus-Host Disease.
by: Ludovic Belle, et al.
Published: (2016-01-01)

Homing and engraftment of CD34+ cells in the NOD/SCID model
by: Ahmed, Forhad
Published: (2005)

Clinical predictors of delayed engraftment in autologous hematopoietic cell transplant recipients
by: Forat Lutfi, et al.
Published: (2020-03-01)

Effect of radiation dose-rate on hematopoietic cell engraftment in adult zebrafish.
by: Tiffany J Glass, et al.
Published: (2013-01-01)

Rational targeting of Cdc42 in hematopoietic stem cell mobilization and engraftment
by: Liu, Wei
Published: (2011)

Dasatinib, high-dose imatinib and nilotinib for the treatment of imatinib-resistant chronic myeloid leukaemia: a systematic review and economic evaluation.
by: E Loveman, et al.
Published: (2012-05-01)