Elevating acetyl-CoA levels reduces aspects of brain aging

Elevating acetyl-CoA levels reduces aspects of brain aging

Because old age is the greatest risk factor for dementia, a successful therapy will require an understanding of the physiological changes that occur in the brain with aging. Here, two structurally distinct Alzheimer's disease (AD) drug candidates, CMS121 and J147, were used to identify a unique...

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Bibliographic Details
Main Authors: Antonio Currais, Ling Huang, Joshua Goldberg, Michael Petrascheck, Gamze Ates, António Pinto-Duarte, Maxim N Shokhirev, David Schubert, Pamela Maher
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
mitochondria
Alzheimer's disease
metabobolomics
transcriptomics
aging
Online Access:https://elifesciences.org/articles/47866

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