Integrating thermodynamic and sequence contexts improves protein-RNA binding prediction.
Predicting RNA-binding protein (RBP) specificity is important for understanding gene expression regulation and RNA-mediated enzymatic processes. It is widely believed that RBP binding specificity is determined by both the sequence and structural contexts of RNAs. Existing approaches, including tradi...
Main Authors: | Yufeng Su, Yunan Luo, Xiaoming Zhao, Yang Liu, Jian Peng |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019-09-01
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Series: | PLoS Computational Biology |
Online Access: | https://doi.org/10.1371/journal.pcbi.1007283 |
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