Probing the influence of mutations on FUS condensates, one molecule at a time
Protein aggregation and phase separation appear to play important roles in diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), but the interplay between different participating molecular events-which may facilitate or inhibit one another-can be difficult to st...
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Online Access: | https://doi.org/10.1038/s42003-020-01560-6 |
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doaj-762ae43a100140e2ad6ddda9465b7a312021-01-10T12:41:38ZengNature Publishing GroupCommunications Biology2399-36422021-01-01411210.1038/s42003-020-01560-6Probing the influence of mutations on FUS condensates, one molecule at a timeKrishnananda Chattopadhyay0Structural Biology and Bioinformatics, CSIR-Indian Institute of Chemical BiologyProtein aggregation and phase separation appear to play important roles in diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), but the interplay between different participating molecular events-which may facilitate or inhibit one another-can be difficult to study by conventional ensemble methods. In a recent study, Kevin Rhine and co-workers make use of point mutations to demonstrate the contrasting behaviour of condensates arising from Glycine and Arginine FUS mutants using single molecules fluorescence measurements.https://doi.org/10.1038/s42003-020-01560-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Krishnananda Chattopadhyay |
spellingShingle |
Krishnananda Chattopadhyay Probing the influence of mutations on FUS condensates, one molecule at a time Communications Biology |
author_facet |
Krishnananda Chattopadhyay |
author_sort |
Krishnananda Chattopadhyay |
title |
Probing the influence of mutations on FUS condensates, one molecule at a time |
title_short |
Probing the influence of mutations on FUS condensates, one molecule at a time |
title_full |
Probing the influence of mutations on FUS condensates, one molecule at a time |
title_fullStr |
Probing the influence of mutations on FUS condensates, one molecule at a time |
title_full_unstemmed |
Probing the influence of mutations on FUS condensates, one molecule at a time |
title_sort |
probing the influence of mutations on fus condensates, one molecule at a time |
publisher |
Nature Publishing Group |
series |
Communications Biology |
issn |
2399-3642 |
publishDate |
2021-01-01 |
description |
Protein aggregation and phase separation appear to play important roles in diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), but the interplay between different participating molecular events-which may facilitate or inhibit one another-can be difficult to study by conventional ensemble methods. In a recent study, Kevin Rhine and co-workers make use of point mutations to demonstrate the contrasting behaviour of condensates arising from Glycine and Arginine FUS mutants using single molecules fluorescence measurements. |
url |
https://doi.org/10.1038/s42003-020-01560-6 |
work_keys_str_mv |
AT krishnanandachattopadhyay probingtheinfluenceofmutationsonfuscondensatesonemoleculeatatime |
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