Probing the influence of mutations on FUS condensates, one molecule at a time

Protein aggregation and phase separation appear to play important roles in diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), but the interplay between different participating molecular events-which may facilitate or inhibit one another-can be difficult to st...

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Main Author: Krishnananda Chattopadhyay
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-020-01560-6
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spelling doaj-762ae43a100140e2ad6ddda9465b7a312021-01-10T12:41:38ZengNature Publishing GroupCommunications Biology2399-36422021-01-01411210.1038/s42003-020-01560-6Probing the influence of mutations on FUS condensates, one molecule at a timeKrishnananda Chattopadhyay0Structural Biology and Bioinformatics, CSIR-Indian Institute of Chemical BiologyProtein aggregation and phase separation appear to play important roles in diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), but the interplay between different participating molecular events-which may facilitate or inhibit one another-can be difficult to study by conventional ensemble methods. In a recent study, Kevin Rhine and co-workers make use of point mutations to demonstrate the contrasting behaviour of condensates arising from Glycine and Arginine FUS mutants using single molecules fluorescence measurements.https://doi.org/10.1038/s42003-020-01560-6
collection DOAJ
language English
format Article
sources DOAJ
author Krishnananda Chattopadhyay
spellingShingle Krishnananda Chattopadhyay
Probing the influence of mutations on FUS condensates, one molecule at a time
Communications Biology
author_facet Krishnananda Chattopadhyay
author_sort Krishnananda Chattopadhyay
title Probing the influence of mutations on FUS condensates, one molecule at a time
title_short Probing the influence of mutations on FUS condensates, one molecule at a time
title_full Probing the influence of mutations on FUS condensates, one molecule at a time
title_fullStr Probing the influence of mutations on FUS condensates, one molecule at a time
title_full_unstemmed Probing the influence of mutations on FUS condensates, one molecule at a time
title_sort probing the influence of mutations on fus condensates, one molecule at a time
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-01-01
description Protein aggregation and phase separation appear to play important roles in diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), but the interplay between different participating molecular events-which may facilitate or inhibit one another-can be difficult to study by conventional ensemble methods. In a recent study, Kevin Rhine and co-workers make use of point mutations to demonstrate the contrasting behaviour of condensates arising from Glycine and Arginine FUS mutants using single molecules fluorescence measurements.
url https://doi.org/10.1038/s42003-020-01560-6
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