The genetics of Ménière’s disease

• Main Authors: Chiarella G, Petrolo C, Cassandro E
• Format: Article
• Language: English
• Published: Dove Medical Press 2015-01-01
• Series: The Application of Clinical Genetics
• Online Access: http://www.dovepress.com/the-genetics-of-meacuteniegraverersquos-disease-peer-reviewed-article-TACG

Giuseppe Chiarella,1 C Petrolo,1 E Cassandro2 1Department of Experimental and Clinical Medicine, Audiology and Phoniatrics Unit, Magna Graecia University of Catanzaro, Catanzaro, Italy; 2Department of Medicine and Surgery, University of Salerno, Salerno, Italy Abstract: Our understanding of the genetic basis of Ménière’s disease (MD) is still limited. Although the familial clustering and the geographical and racial differences in incidence strongly suggest a certain role for genetic factors in the development of MD, no convincing evidence for an association with any gene exists, at present. In this review, starting from rational bases for a genetic approach to MD, we explored the numerous reports published in literature and summarize the recent advances in understanding of the genetic fundaments of the disease. Keywords: Mènière’s disease, gene, vertigo, etiology, pathogenesis