Ground state destabilization by anionic nucleophiles contributes to the activity of phosphoryl transfer enzymes.
Enzymes stabilize transition states of reactions while limiting binding to ground states, as is generally required for any catalyst. Alkaline Phosphatase (AP) and other nonspecific phosphatases are some of Nature's most impressive catalysts, achieving preferential transition state over ground s...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-07-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC3699461?pdf=render |