Optogenetic Hyperpolarization of Cardiomyocytes Terminates Ventricular Arrhythmia

Optogenetic Hyperpolarization of Cardiomyocytes Terminates Ventricular Arrhythmia

Cardiac defibrillation to terminate lethal ventricular arrhythmia (VA) is currently performed by applying high energy electrical shocks. In cardiac tissue, electrical shocks induce simultaneously de- and hyperpolarized areas and only depolarized areas are considered to be responsible for VA terminat...

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Bibliographic Details
Main Authors: Maximilian Funken, Daniela Malan, Philipp Sasse, Tobias Bruegmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Physiology
Subjects:
optogenetics
archaerhodopsin
ventricular arrhythmia
defibrillation
hyperpolarization
electrophysiology
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00498/full

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