Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance

Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance

Abstract Background Malaria remains a major public health burden and resistance has emerged to every antimalarial on the market, including the frontline drug, artemisinin. Our limited understanding of Plasmodium biology hinders the elucidation of resistance mechanisms. In this regard, systems biolog...

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Bibliographic Details
Main Authors: Maureen A. Carey, Jason A. Papin, Jennifer L. Guler
Format: Article
Language:English
Published: BMC 2017-07-01
Series:BMC Genomics
Subjects:
Plasmodium falciparum
Malaria
Metabolism
Network reconstruction
Artemisinin resistance
Flux balance analysis
Online Access:http://link.springer.com/article/10.1186/s12864-017-3905-1

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http://link.springer.com/article/10.1186/s12864-017-3905-1

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