A Polymer for Application as a Matrix Phase in a Concept of In Situ Curable Bioresorbable Bioactive Load-Bearing Continuous Fiber Reinforced Composite Fracture Fixation Plates
The use of bioresorbable fracture fixation plates made of aliphatic polyesters have good potential due to good biocompatibility, reduced risk of stress-shielding, and eliminated need for plate removal. However, polyesters are ductile, and their handling properties are limited. We suggested an altern...
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MDPI AG
2021-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/5/1256 |
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doaj-75f4c479c3594296b185a3d66f8e360e2021-02-27T00:01:21ZengMDPI AGMolecules1420-30492021-02-01261256125610.3390/molecules26051256A Polymer for Application as a Matrix Phase in a Concept of In Situ Curable Bioresorbable Bioactive Load-Bearing Continuous Fiber Reinforced Composite Fracture Fixation PlatesArtem Plyusnin0Jingwei He1Cindy Elschner2Miho Nakamura3Julia Kulkova4Axel Spickenheuer5Christina Scheffler6Lippo V. J. Lassila7Niko Moritz8Department of Biomaterials Science and Turku Clinical Biomaterials Centre—TCBC, Institute of Dentistry, Faculty of Medicine, University of Turku, FI-20014 Turku, FinlandCollege of Materials Science and Engineering, South China University of Technology, Guangzhou 510006, ChinaLeibniz-Institut für Polymerforschung Dresden e. V., D-01005 Dresden, GermanyMedicity Research Laboratory, Faculty of Medicine, University of Turku, FI-20014 Turku, FinlandDepartment of Biomaterials Science and Turku Clinical Biomaterials Centre—TCBC, Institute of Dentistry, Faculty of Medicine, University of Turku, FI-20014 Turku, FinlandLeibniz-Institut für Polymerforschung Dresden e. V., D-01005 Dresden, GermanyLeibniz-Institut für Polymerforschung Dresden e. V., D-01005 Dresden, GermanyDepartment of Biomaterials Science and Turku Clinical Biomaterials Centre—TCBC, Institute of Dentistry, Faculty of Medicine, University of Turku, FI-20014 Turku, FinlandDepartment of Biomaterials Science and Turku Clinical Biomaterials Centre—TCBC, Institute of Dentistry, Faculty of Medicine, University of Turku, FI-20014 Turku, FinlandThe use of bioresorbable fracture fixation plates made of aliphatic polyesters have good potential due to good biocompatibility, reduced risk of stress-shielding, and eliminated need for plate removal. However, polyesters are ductile, and their handling properties are limited. We suggested an alternative, PLAMA (PolyLActide functionalized with diMethAcrylate), for the use as the matrix phase for the novel concept of the in situ curable bioresorbable load-bearing composite plate to reduce the limitations of conventional polyesters. The purpose was to obtain a preliminary understanding of the chemical and physical properties and the biological safety of PLAMA from the prospective of the novel concept. Modifications with different molecular masses (PLAMA-500 and PLAMA-1000) were synthesized. The efficiency of curing was assessed by the degree of convergence (DC). The mechanical properties were obtained by tensile test and thermomechanical analysis. The bioresorbability was investigated by immersion in simulated body fluid. The biocompatibility was studied in cell morphology and viability tests. PLAMA-500 showed better DC and mechanical properties, and slower bioresorbability than PLAMA-1000. Both did not prevent proliferation and normal morphological development of cells. We concluded that PLAMA-500 has potential for the use as the matrix material for bioresorbable load-bearing composite fracture fixation plates.https://www.mdpi.com/1420-3049/26/5/1256functionalized polylactidebioresorbable composite matrixlight curable polymerless-rigid fracture fixationbioresorbable FRC. |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Artem Plyusnin Jingwei He Cindy Elschner Miho Nakamura Julia Kulkova Axel Spickenheuer Christina Scheffler Lippo V. J. Lassila Niko Moritz |
| spellingShingle |
Artem Plyusnin Jingwei He Cindy Elschner Miho Nakamura Julia Kulkova Axel Spickenheuer Christina Scheffler Lippo V. J. Lassila Niko Moritz A Polymer for Application as a Matrix Phase in a Concept of In Situ Curable Bioresorbable Bioactive Load-Bearing Continuous Fiber Reinforced Composite Fracture Fixation Plates Molecules functionalized polylactide bioresorbable composite matrix light curable polymer less-rigid fracture fixation bioresorbable FRC. |
| author_facet |
Artem Plyusnin Jingwei He Cindy Elschner Miho Nakamura Julia Kulkova Axel Spickenheuer Christina Scheffler Lippo V. J. Lassila Niko Moritz |
| author_sort |
Artem Plyusnin |
| title |
A Polymer for Application as a Matrix Phase in a Concept of In Situ Curable Bioresorbable Bioactive Load-Bearing Continuous Fiber Reinforced Composite Fracture Fixation Plates |
| title_short |
A Polymer for Application as a Matrix Phase in a Concept of In Situ Curable Bioresorbable Bioactive Load-Bearing Continuous Fiber Reinforced Composite Fracture Fixation Plates |
| title_full |
A Polymer for Application as a Matrix Phase in a Concept of In Situ Curable Bioresorbable Bioactive Load-Bearing Continuous Fiber Reinforced Composite Fracture Fixation Plates |
| title_fullStr |
A Polymer for Application as a Matrix Phase in a Concept of In Situ Curable Bioresorbable Bioactive Load-Bearing Continuous Fiber Reinforced Composite Fracture Fixation Plates |
| title_full_unstemmed |
A Polymer for Application as a Matrix Phase in a Concept of In Situ Curable Bioresorbable Bioactive Load-Bearing Continuous Fiber Reinforced Composite Fracture Fixation Plates |
| title_sort |
polymer for application as a matrix phase in a concept of in situ curable bioresorbable bioactive load-bearing continuous fiber reinforced composite fracture fixation plates |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2021-02-01 |
| description |
The use of bioresorbable fracture fixation plates made of aliphatic polyesters have good potential due to good biocompatibility, reduced risk of stress-shielding, and eliminated need for plate removal. However, polyesters are ductile, and their handling properties are limited. We suggested an alternative, PLAMA (PolyLActide functionalized with diMethAcrylate), for the use as the matrix phase for the novel concept of the in situ curable bioresorbable load-bearing composite plate to reduce the limitations of conventional polyesters. The purpose was to obtain a preliminary understanding of the chemical and physical properties and the biological safety of PLAMA from the prospective of the novel concept. Modifications with different molecular masses (PLAMA-500 and PLAMA-1000) were synthesized. The efficiency of curing was assessed by the degree of convergence (DC). The mechanical properties were obtained by tensile test and thermomechanical analysis. The bioresorbability was investigated by immersion in simulated body fluid. The biocompatibility was studied in cell morphology and viability tests. PLAMA-500 showed better DC and mechanical properties, and slower bioresorbability than PLAMA-1000. Both did not prevent proliferation and normal morphological development of cells. We concluded that PLAMA-500 has potential for the use as the matrix material for bioresorbable load-bearing composite fracture fixation plates. |
| topic |
functionalized polylactide bioresorbable composite matrix light curable polymer less-rigid fracture fixation bioresorbable FRC. |
| url |
https://www.mdpi.com/1420-3049/26/5/1256 |
| work_keys_str_mv |
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