Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes

Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes

Genetic variation drives phenotypic diversity and influences the predisposition to metabolic disease. Here, we characterize the metabolic phenotypes of eight genetically distinct inbred mouse strains in response to a high-fat/high-sucrose diet. We found significant variation in diabetes-related phen...

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Bibliographic Details
Main Authors: Julia H. Kreznar, Mark P. Keller, Lindsay L. Traeger, Mary E. Rabaglia, Kathryn L. Schueler, Donald S. Stapleton, Wen Zhao, Eugenio I. Vivas, Brian S. Yandell, Aimee Teo Broman, Bruno Hagenbuch, Alan D. Attie, Federico E. Rey
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Subjects:
metabolic disease
gut microbiome
pancreatic islets
insulin secretion
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717301195

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http://www.sciencedirect.com/science/article/pii/S2211124717301195

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