Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol
Background: The protocol study will focus on the seroprevalence of IgG antibodies to SARS-CoV-2 achieved by vaccination and/or natural protection as well as the history, symptoms, and risk factors for SARS-CoV-2 in four primary health-care workers (PHCWs) and their household contacts in metropolitan...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/10/7/911 |
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doaj-75ef2b6d798e4e45b3ea8a6ce712879d |
|---|---|
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Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Marie Pouquet Dorine Decarreaux Pol Prévot-Monsacré Corentin Hervé Andréas Werner Brigitte Grosgogeat Hélène Blanché Pascaline Rabiega Julien Laupie Fabienne Kochert Nathalie Abraham Jean-Marc Sebaoun Xavier de Lamballerie Remi Charrel Cecile Souty Ibrahima Camara Jeanne Pergeline Harold Noël Caroline Guerrisi Sylvie van der Werf Fabrice Carrat Thomas Hanslik Thierry Blanchon Alessandra Falchi |
| spellingShingle |
Marie Pouquet Dorine Decarreaux Pol Prévot-Monsacré Corentin Hervé Andréas Werner Brigitte Grosgogeat Hélène Blanché Pascaline Rabiega Julien Laupie Fabienne Kochert Nathalie Abraham Jean-Marc Sebaoun Xavier de Lamballerie Remi Charrel Cecile Souty Ibrahima Camara Jeanne Pergeline Harold Noël Caroline Guerrisi Sylvie van der Werf Fabrice Carrat Thomas Hanslik Thierry Blanchon Alessandra Falchi Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol Pathogens SARS-CoV-2 seroprevalence vaccination primary health-care workers household |
| author_facet |
Marie Pouquet Dorine Decarreaux Pol Prévot-Monsacré Corentin Hervé Andréas Werner Brigitte Grosgogeat Hélène Blanché Pascaline Rabiega Julien Laupie Fabienne Kochert Nathalie Abraham Jean-Marc Sebaoun Xavier de Lamballerie Remi Charrel Cecile Souty Ibrahima Camara Jeanne Pergeline Harold Noël Caroline Guerrisi Sylvie van der Werf Fabrice Carrat Thomas Hanslik Thierry Blanchon Alessandra Falchi |
| author_sort |
Marie Pouquet |
| title |
Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol |
| title_short |
Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol |
| title_full |
Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol |
| title_fullStr |
Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol |
| title_full_unstemmed |
Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol |
| title_sort |
nationwide seroprevalence of sars-cov-2 igg antibodies among four groups of primary health-care workers and their household contacts 6 months after the initiation of the covid-19 vaccination campaign in france: seroprim study protocol |
| publisher |
MDPI AG |
| series |
Pathogens |
| issn |
2076-0817 |
| publishDate |
2021-07-01 |
| description |
Background: The protocol study will focus on the seroprevalence of IgG antibodies to SARS-CoV-2 achieved by vaccination and/or natural protection as well as the history, symptoms, and risk factors for SARS-CoV-2 in four primary health-care workers (PHCWs) and their household contacts in metropolitan France. Methods: Here, we propose a protocol for a nationwide survey to determine the seroprevalence of IgG antibodies to SARS-CoV-2 achieved by vaccination and/or natural protection in four PHCW populations (general practitioners, pediatricians, pharmacists and assistants, and dentists and assistants) and their household contacts. Participants will be included from June to July 2021 (Phase 1) among PHCW populations located throughout metropolitan France. They will be asked to provide a range of demographic and behavioral information since the first SARS-CoV-2 wave and a self-sampled dried blood spot. Phase 1 will involve also a questionnaire and serological study of PHCWs’ household contacts. Seroprevalence will be estimated using two ELISAs designed to detect specific IgG antibodies to SARS-CoV-2 in humoral fluid, and these results will be confirmed using a virus neutralization test. This study will be repeated from November to December 2021 (Phase 2) to evaluate the evolution of immune status achieved by vaccination and/or natural protection of PHCWs and to describe the history of exposure to SARS-CoV-2. |
| topic |
SARS-CoV-2 seroprevalence vaccination primary health-care workers household |
| url |
https://www.mdpi.com/2076-0817/10/7/911 |
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doaj-75ef2b6d798e4e45b3ea8a6ce712879d2021-07-23T13:59:45ZengMDPI AGPathogens2076-08172021-07-011091191110.3390/pathogens10070911Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study ProtocolMarie Pouquet0Dorine Decarreaux1Pol Prévot-Monsacré2Corentin Hervé3Andréas Werner4Brigitte Grosgogeat5Hélène Blanché6Pascaline Rabiega7Julien Laupie8Fabienne Kochert9Nathalie Abraham10Jean-Marc Sebaoun11Xavier de Lamballerie12Remi Charrel13Cecile Souty14Ibrahima Camara15Jeanne Pergeline16Harold Noël17Caroline Guerrisi18Sylvie van der Werf19Fabrice Carrat20Thomas Hanslik21Thierry Blanchon22Alessandra Falchi23INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, (IPLESP), Sorbonne Université, 75012 Paris, FranceINSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, (IPLESP), Sorbonne Université, 75012 Paris, FranceINSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, (IPLESP), Sorbonne Université, 75012 Paris, FranceINSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, (IPLESP), Sorbonne Université, 75012 Paris, FranceAssociation Française de Pédiatrie Ambulatoire (AFPA), 69000 Orléans, FranceFaculté d’Odontologie, Université Claude Bernard Lyon 1, Université de Lyon, 69000 Lyon, FranceFondation Jean Dausset-CEPH, 75000 Paris, FranceIQVIA, Réseau de Pharmaciens, 75000 Paris, FranceRéseau ReCOL, Association Dentaire Française, 75000 Paris, FranceAssociation Française de Pédiatrie Ambulatoire (AFPA), 69000 Orléans, FranceIQVIA, Réseau de Pharmaciens, 75000 Paris, FranceFondation Jean Dausset-CEPH, 75000 Paris, FranceUnité des Virus Emergents, Aix Marseille University, IRD 190, INSERM U1207, 13005 Marseille, FranceUnité des Virus Emergents, Aix Marseille University, IRD 190, INSERM U1207, 13005 Marseille, FranceINSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, (IPLESP), Sorbonne Université, 75012 Paris, FranceINSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, (IPLESP), Sorbonne Université, 75012 Paris, FranceINSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, (IPLESP), Sorbonne Université, 75012 Paris, FranceInfectious Diseases Division, Santé Publique France, 94410 Saint Maurice, FranceINSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, (IPLESP), Sorbonne Université, 75012 Paris, FranceUnit of Molecular Genetics of RNA Viruses, UMR 3569 CNRS, Institut Pasteur, University of Paris-Diderot, 75000 Paris, FranceINSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, (IPLESP), Sorbonne Université, 75012 Paris, FranceINSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, (IPLESP), Sorbonne Université, 75012 Paris, FranceINSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, (IPLESP), Sorbonne Université, 75012 Paris, FranceLaboratoire de Virologie, Université de Corse Pascal Paoli, UR7310 BioScope, 20250 Corte, FranceBackground: The protocol study will focus on the seroprevalence of IgG antibodies to SARS-CoV-2 achieved by vaccination and/or natural protection as well as the history, symptoms, and risk factors for SARS-CoV-2 in four primary health-care workers (PHCWs) and their household contacts in metropolitan France. Methods: Here, we propose a protocol for a nationwide survey to determine the seroprevalence of IgG antibodies to SARS-CoV-2 achieved by vaccination and/or natural protection in four PHCW populations (general practitioners, pediatricians, pharmacists and assistants, and dentists and assistants) and their household contacts. Participants will be included from June to July 2021 (Phase 1) among PHCW populations located throughout metropolitan France. They will be asked to provide a range of demographic and behavioral information since the first SARS-CoV-2 wave and a self-sampled dried blood spot. Phase 1 will involve also a questionnaire and serological study of PHCWs’ household contacts. Seroprevalence will be estimated using two ELISAs designed to detect specific IgG antibodies to SARS-CoV-2 in humoral fluid, and these results will be confirmed using a virus neutralization test. This study will be repeated from November to December 2021 (Phase 2) to evaluate the evolution of immune status achieved by vaccination and/or natural protection of PHCWs and to describe the history of exposure to SARS-CoV-2.https://www.mdpi.com/2076-0817/10/7/911SARS-CoV-2seroprevalencevaccinationprimary health-care workershousehold |