LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast

LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast

A functional telomerase complex requires that the catalytic TERT subunit be assembled with the template RNA TER1. Here the authors show that Pof8, a possible LARP7 family protein, is required for assembly of the telomerase complex, and repression of lncRNA transcripts at telomeres in S. pombe.

Bibliographic Details
Main Authors: Amanda K. Mennie, Bettina A. Moser, Toru M. Nakamura
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-02874-0
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spelling doaj-75e94b3c5a5045c4a231fd702af774f52021-05-11T09:29:25ZengNature Publishing GroupNature Communications2041-17232018-02-019111210.1038/s41467-018-02874-0LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeastAmanda K. Mennie0Bettina A. Moser1Toru M. Nakamura2Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at ChicagoDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at ChicagoDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at ChicagoA functional telomerase complex requires that the catalytic TERT subunit be assembled with the template RNA TER1. Here the authors show that Pof8, a possible LARP7 family protein, is required for assembly of the telomerase complex, and repression of lncRNA transcripts at telomeres in S. pombe.https://doi.org/10.1038/s41467-018-02874-0
collection DOAJ
language English
format Article
sources DOAJ
author Amanda K. Mennie
Bettina A. Moser
Toru M. Nakamura
spellingShingle Amanda K. Mennie
Bettina A. Moser
Toru M. Nakamura
LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast
Nature Communications
author_facet Amanda K. Mennie
Bettina A. Moser
Toru M. Nakamura
author_sort Amanda K. Mennie
title LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast
title_short LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast
title_full LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast
title_fullStr LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast
title_full_unstemmed LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast
title_sort larp7-like protein pof8 regulates telomerase assembly and poly(a)+terra expression in fission yeast
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-02-01
description A functional telomerase complex requires that the catalytic TERT subunit be assembled with the template RNA TER1. Here the authors show that Pof8, a possible LARP7 family protein, is required for assembly of the telomerase complex, and repression of lncRNA transcripts at telomeres in S. pombe.
url https://doi.org/10.1038/s41467-018-02874-0
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AT bettinaamoser larp7likeproteinpof8regulatestelomeraseassemblyandpolyaterraexpressioninfissionyeast
AT torumnakamura larp7likeproteinpof8regulatestelomeraseassemblyandpolyaterraexpressioninfissionyeast
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