Sex-dependent effects of developmental arsenic exposure on methylation capacity and methylation regulation of the glucocorticoid receptor system in the embryonic mouse brain

Sex-dependent effects of developmental arsenic exposure on methylation capacity and methylation regulation of the glucocorticoid receptor system in the embryonic mouse brain

Previously we have shown that prenatal moderate arsenic exposure (50 ppb) disrupts glucocorticoid receptor (GR) programming and that these changes continue into adolescence in males. However, it was not clear what the molecular mechanisms were promoting these GR programming changes or if these chang...

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Bibliographic Details
Main Authors: Andrea M. Allan, Alexander K. Hafez, Matthew T. Labrecque, Elizabeth R. Solomon, M. Nabil Shaikh, Xianyun Zheng, Abdulmehdi Ali
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Toxicology Reports
Subjects:
Arsenate
Prenatal
Glucocorticoid
11B-Hydroxysteroid
Dehydrogenase-1
DNA methylation
glutathione
S-adenosylmethionine
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750015300676

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http://www.sciencedirect.com/science/article/pii/S2214750015300676

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