In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging System

Absorption contrast between the terahertz (THz) frequency range of fatty and cancer tissues allows cancer diagnosis by THz imaging. We successfully demonstrated the ability of THz imaging to measure small breast cancer volume in the subcutaneous xenotransplantation mouse models even without external...

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Main Authors:	Hua Chen, Juan Han, Dan Wang, Yu Zhang, Xiao Li, Xiaofeng Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Series:	Frontiers in Genetics
Subjects:	THz imaging mouse model breast cancer caner volume
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2021.700086/full

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spelling	doaj-75da9405c6d14e578ace45b5f65e68f02021-09-27T05:20:17ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-09-011210.3389/fgene.2021.700086700086In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging SystemHua Chen0Juan Han1Dan Wang2Yu Zhang3Xiao Li4Xiaofeng Chen5School of Physics, Southeast University, Nanjing, ChinaSchool of Physics, Southeast University, Nanjing, ChinaSchool of Physics, Southeast University, Nanjing, ChinaSchool of Physics, Southeast University, Nanjing, ChinaThe First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaThe First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaAbsorption contrast between the terahertz (THz) frequency range of fatty and cancer tissues allows cancer diagnosis by THz imaging. We successfully demonstrated the ability of THz imaging to measure small breast cancer volume in the subcutaneous xenotransplantation mouse models even without external comparison. We estimated the volume detection limitation of the fiber-based THz scanning imaging system using a highly sensitive cryogenic-temperature-operated Schottky diode detector to be smaller than 1 mm3, thus showing the potential application of this technique in preliminary early cancer diagnosis.https://www.frontiersin.org/articles/10.3389/fgene.2021.700086/fullTHzimagingmouse modelbreast cancercaner volume
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hua Chen Juan Han Dan Wang Yu Zhang Xiao Li Xiaofeng Chen
spellingShingle	Hua Chen Juan Han Dan Wang Yu Zhang Xiao Li Xiaofeng Chen In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging System Frontiers in Genetics THz imaging mouse model breast cancer caner volume
author_facet	Hua Chen Juan Han Dan Wang Yu Zhang Xiao Li Xiaofeng Chen
author_sort	Hua Chen
title	In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging System
title_short	In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging System
title_full	In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging System
title_fullStr	In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging System
title_full_unstemmed	In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging System
title_sort	in vivo estimation of breast cancer tissue volume in subcutaneous xenotransplantation mouse models by using a high-sensitivity fiber-based terahertz scanning imaging system
publisher	Frontiers Media S.A.
series	Frontiers in Genetics
issn	1664-8021
publishDate	2021-09-01
description	Absorption contrast between the terahertz (THz) frequency range of fatty and cancer tissues allows cancer diagnosis by THz imaging. We successfully demonstrated the ability of THz imaging to measure small breast cancer volume in the subcutaneous xenotransplantation mouse models even without external comparison. We estimated the volume detection limitation of the fiber-based THz scanning imaging system using a highly sensitive cryogenic-temperature-operated Schottky diode detector to be smaller than 1 mm3, thus showing the potential application of this technique in preliminary early cancer diagnosis.
topic	THz imaging mouse model breast cancer caner volume
url	https://www.frontiersin.org/articles/10.3389/fgene.2021.700086/full
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In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging System

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