The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

Cholesterol 24S-hydroxylase (CYP46A1) is of key importance for cholesterol homeostasis in the brain. This enzyme seems to be resistant toward most regulatory factors and at present no drug effects on its activity have been described. The crystal structures of the substrate-free and substrate-bound C...

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Bibliographic Details
Main Authors: Marjan Shafaati, Natalia Mast, Olof Beck, Rima Nayef, Gun Young Heo, Linda Björkhem-Bergman, Dieter Lütjohann, Ingemar Björkhem, Irina A. Pikuleva
Format: Article
Language:English
Published: Elsevier 2010-02-01
Series:Journal of Lipid Research
Subjects:
cholesterol biosynthesis
cholesterol elimination
brain
visual disturbances
retina
side effects
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520305368

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http://www.sciencedirect.com/science/article/pii/S0022227520305368

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