Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

Sterol homeostasis is essential for the function of cellular membranes and requires feedback inhibition of HMGR, a rate-limiting enzyme of the mevalonate pathway. As HMGR acts at the beginning of the pathway, its regulation affects the synthesis of sterols and of other essential mevalonate-derived m...

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Bibliographic Details
Main Authors: Ombretta Foresti, Annamaria Ruggiano, Hans K Hannibal-Bach, Christer S Ejsing, Pedro Carvalho
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-07-01
Series:eLife
Subjects:
endoplasmic reticulum
ERAD
sterol homeostasis
squalene monooxygenase
DOA10
TEB4
Online Access:https://elifesciences.org/articles/00953

Internet

https://elifesciences.org/articles/00953

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