Investigation of SCUBE-1 levels in pediatric patients with beta-thalassemia

• Main Authors: Behiye Nurten Seringeç Akkeçeci, Sevcan İpek, Can Acıpayam, Fatma İnanç Tolun, Defne Ay Tuncel, Hatice Güneş, Ömer Duyuran
• Format: Article
• Language: English
• Published: Journal of Surgery and Medicine 2019-12-01
• Series: Journal of Surgery and Medicine
• Subjects: beta-talasemi major; çocuklar; scube-1; tromboz; beta-thalassemia major; children; thrombosis
• Online Access: https://dergipark.org.tr/en/pub/josam/issue/50441/653402
• ISSN: 2602-2079

Aim: A thrombosis and inflammation marker, Signal peptide-CUB (complement C1r/C1 s)-EGF (epidermal growth factor)-like domain-containing protein 1 (SCUBE-1) is expressed in endothelial cells and activated platelets. We aimed to investigate the levels of this marker in patients with Thalassemia major (TM), a disease which causes a tendency to thrombosis.Methods: Twenty patients with TM and age and gender-matched twenty healthy controls were included in this prospective case-control study. Other thrombosis markers such as D-dimer and homocysteine were studied in addition to SCUBE-1 in both groups.Results: The SCUBE1 and D-dimer levels were higher in the TM group compared to the control group (P=0.004, P=0.023, respectively). A significant positive correlation was detected between platelet count and SCUBE1 (r=0.342, P=0.031).Conclusion: We detected elevated SCUBE1 levels in children with TM compared to the healthy controls, which correlated with platelet count. SCUBE1 may be used as a thrombosis marker in TM in the early stages of the disease.