Nitric Oxide-Releasing Aspirin Suppresses NF-κB Signaling in Estrogen Receptor Negative Breast Cancer Cells in Vitro and in Vivo

Nitric Oxide-Releasing Aspirin Suppresses NF-κB Signaling in Estrogen Receptor Negative Breast Cancer Cells in Vitro and in Vivo

Estrogen receptor negative (ER(−)) breast cancer is aggressive, responds poorly to current treatments and has a poor prognosis. The NF-κB signaling pathway is implicated in ER(−) tumorigenesis. Aspirin (ASA) is chemopreventive against ER(+) but not for ER(−) breast cancers. Nitric oxide-releasing as...

Full description

Bibliographic Details
Main Authors: Niharika Nath, Mitali Chattopadhyay, Deborah B. Rodes, Anna Nazarenko, Ravinder Kodela, Khosrow Kashfi
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Molecules
Subjects:
NSAIDs
NO-NSAIDs
NF-κB
oxidative stress
breast cancer
estrogen receptor
Online Access:http://www.mdpi.com/1420-3049/20/7/12481

Internet

http://www.mdpi.com/1420-3049/20/7/12481

Similar Items