Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy

Abstract Combined chemo/chemodynamic therapy is a promising strategy to achieve an improved anticancer effect. However, the hypoxic microenvironment and limited amount of H2O2 in most solid tumors severely restrict the efficacy of this treatment. Herein, the construction of a nanocatalytic medicine,...

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Main Authors: Shutao Gao, Yan Jin, Kun Ge, Zhenhua Li, Huifang Liu, Xinyue Dai, Yinghua Zhang, Shizhu Chen, Xingjie Liang, Jinchao Zhang
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Advanced Science
Subjects:
Online Access:https://doi.org/10.1002/advs.201902137
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spelling doaj-75be41948311431584d88de049bc749b2020-11-25T02:21:27ZengWileyAdvanced Science2198-38442019-12-01624n/an/a10.1002/advs.201902137Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic TherapyShutao Gao0Yan Jin1Kun Ge2Zhenhua Li3Huifang Liu4Xinyue Dai5Yinghua Zhang6Shizhu Chen7Xingjie Liang8Jinchao Zhang9College of Chemistry & Environmental Science Analytical Chemistry Key Laboratory of Hebei Province Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University Baoding 071002 P. R. ChinaCollege of Chemistry & Environmental Science Analytical Chemistry Key Laboratory of Hebei Province Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University Baoding 071002 P. R. ChinaCollege of Chemistry & Environmental Science Analytical Chemistry Key Laboratory of Hebei Province Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University Baoding 071002 P. R. ChinaCollege of Chemistry & Environmental Science Analytical Chemistry Key Laboratory of Hebei Province Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University Baoding 071002 P. R. ChinaCollege of Chemistry & Environmental Science Analytical Chemistry Key Laboratory of Hebei Province Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University Baoding 071002 P. R. ChinaCollege of Chemistry & Environmental Science Analytical Chemistry Key Laboratory of Hebei Province Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University Baoding 071002 P. R. ChinaCollege of Chemistry & Environmental Science Analytical Chemistry Key Laboratory of Hebei Province Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University Baoding 071002 P. R. ChinaCAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Beijing 100190 P. R. ChinaCAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Beijing 100190 P. R. ChinaCollege of Chemistry & Environmental Science Analytical Chemistry Key Laboratory of Hebei Province Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University Baoding 071002 P. R. ChinaAbstract Combined chemo/chemodynamic therapy is a promising strategy to achieve an improved anticancer effect. However, the hypoxic microenvironment and limited amount of H2O2 in most solid tumors severely restrict the efficacy of this treatment. Herein, the construction of a nanocatalytic medicine, CaO2@DOX@ZIF‐67, via a bottom‐up approach is described. CaO2@DOX@ZIF‐67 simultaneously supplies O2 and H2O2 to achieve improved chemo/chemodynamic therapy. In the weakly acidic environment within tumors, CaO2@DOX@ZIF‐67 is broken down to rapidly release the Fenton‐like catalyst Co2+ and the chemotherapy drug doxorubicin (DOX). The unprotected CaO2 reacts with H2O to generate both O2 and H2O2. The generated O2 relieves the hypoxia in the tumor and further improve the efficacy of DOX. Meanwhile, the generated H2O2 reacts with Co2+ ions to produce highly toxic •OH through a Fenton‐like reaction, resulting in improved chemodynamic therapy.https://doi.org/10.1002/advs.201902137CaO2chemodynamic therapychemotherapydoxorubicinZIF‐67
collection DOAJ
language English
format Article
sources DOAJ
author Shutao Gao
Yan Jin
Kun Ge
Zhenhua Li
Huifang Liu
Xinyue Dai
Yinghua Zhang
Shizhu Chen
Xingjie Liang
Jinchao Zhang
spellingShingle Shutao Gao
Yan Jin
Kun Ge
Zhenhua Li
Huifang Liu
Xinyue Dai
Yinghua Zhang
Shizhu Chen
Xingjie Liang
Jinchao Zhang
Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy
Advanced Science
CaO2
chemodynamic therapy
chemotherapy
doxorubicin
ZIF‐67
author_facet Shutao Gao
Yan Jin
Kun Ge
Zhenhua Li
Huifang Liu
Xinyue Dai
Yinghua Zhang
Shizhu Chen
Xingjie Liang
Jinchao Zhang
author_sort Shutao Gao
title Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy
title_short Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy
title_full Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy
title_fullStr Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy
title_full_unstemmed Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy
title_sort self‐supply of o2 and h2o2 by a nanocatalytic medicine to enhance combined chemo/chemodynamic therapy
publisher Wiley
series Advanced Science
issn 2198-3844
publishDate 2019-12-01
description Abstract Combined chemo/chemodynamic therapy is a promising strategy to achieve an improved anticancer effect. However, the hypoxic microenvironment and limited amount of H2O2 in most solid tumors severely restrict the efficacy of this treatment. Herein, the construction of a nanocatalytic medicine, CaO2@DOX@ZIF‐67, via a bottom‐up approach is described. CaO2@DOX@ZIF‐67 simultaneously supplies O2 and H2O2 to achieve improved chemo/chemodynamic therapy. In the weakly acidic environment within tumors, CaO2@DOX@ZIF‐67 is broken down to rapidly release the Fenton‐like catalyst Co2+ and the chemotherapy drug doxorubicin (DOX). The unprotected CaO2 reacts with H2O to generate both O2 and H2O2. The generated O2 relieves the hypoxia in the tumor and further improve the efficacy of DOX. Meanwhile, the generated H2O2 reacts with Co2+ ions to produce highly toxic •OH through a Fenton‐like reaction, resulting in improved chemodynamic therapy.
topic CaO2
chemodynamic therapy
chemotherapy
doxorubicin
ZIF‐67
url https://doi.org/10.1002/advs.201902137
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