Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy
Abstract Combined chemo/chemodynamic therapy is a promising strategy to achieve an improved anticancer effect. However, the hypoxic microenvironment and limited amount of H2O2 in most solid tumors severely restrict the efficacy of this treatment. Herein, the construction of a nanocatalytic medicine,...
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doaj-75be41948311431584d88de049bc749b2020-11-25T02:21:27ZengWileyAdvanced Science2198-38442019-12-01624n/an/a10.1002/advs.201902137Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic TherapyShutao Gao0Yan Jin1Kun Ge2Zhenhua Li3Huifang Liu4Xinyue Dai5Yinghua Zhang6Shizhu Chen7Xingjie Liang8Jinchao Zhang9College of Chemistry & Environmental Science Analytical Chemistry Key Laboratory of Hebei Province Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University Baoding 071002 P. R. ChinaCollege of Chemistry & Environmental Science Analytical Chemistry Key Laboratory of Hebei Province Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University Baoding 071002 P. R. ChinaCollege of Chemistry & Environmental Science Analytical Chemistry Key Laboratory of Hebei Province Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University Baoding 071002 P. R. ChinaCollege of Chemistry & Environmental Science Analytical Chemistry Key Laboratory of Hebei Province Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University Baoding 071002 P. R. ChinaCollege of Chemistry & Environmental Science Analytical Chemistry Key Laboratory of Hebei Province Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University Baoding 071002 P. R. ChinaCollege of Chemistry & Environmental Science Analytical Chemistry Key Laboratory of Hebei Province Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University Baoding 071002 P. R. ChinaCollege of Chemistry & Environmental Science Analytical Chemistry Key Laboratory of Hebei Province Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University Baoding 071002 P. R. ChinaCAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Beijing 100190 P. R. ChinaCAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Beijing 100190 P. R. ChinaCollege of Chemistry & Environmental Science Analytical Chemistry Key Laboratory of Hebei Province Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University Baoding 071002 P. R. ChinaAbstract Combined chemo/chemodynamic therapy is a promising strategy to achieve an improved anticancer effect. However, the hypoxic microenvironment and limited amount of H2O2 in most solid tumors severely restrict the efficacy of this treatment. Herein, the construction of a nanocatalytic medicine, CaO2@DOX@ZIF‐67, via a bottom‐up approach is described. CaO2@DOX@ZIF‐67 simultaneously supplies O2 and H2O2 to achieve improved chemo/chemodynamic therapy. In the weakly acidic environment within tumors, CaO2@DOX@ZIF‐67 is broken down to rapidly release the Fenton‐like catalyst Co2+ and the chemotherapy drug doxorubicin (DOX). The unprotected CaO2 reacts with H2O to generate both O2 and H2O2. The generated O2 relieves the hypoxia in the tumor and further improve the efficacy of DOX. Meanwhile, the generated H2O2 reacts with Co2+ ions to produce highly toxic •OH through a Fenton‐like reaction, resulting in improved chemodynamic therapy.https://doi.org/10.1002/advs.201902137CaO2chemodynamic therapychemotherapydoxorubicinZIF‐67 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shutao Gao Yan Jin Kun Ge Zhenhua Li Huifang Liu Xinyue Dai Yinghua Zhang Shizhu Chen Xingjie Liang Jinchao Zhang |
spellingShingle |
Shutao Gao Yan Jin Kun Ge Zhenhua Li Huifang Liu Xinyue Dai Yinghua Zhang Shizhu Chen Xingjie Liang Jinchao Zhang Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy Advanced Science CaO2 chemodynamic therapy chemotherapy doxorubicin ZIF‐67 |
author_facet |
Shutao Gao Yan Jin Kun Ge Zhenhua Li Huifang Liu Xinyue Dai Yinghua Zhang Shizhu Chen Xingjie Liang Jinchao Zhang |
author_sort |
Shutao Gao |
title |
Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy |
title_short |
Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy |
title_full |
Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy |
title_fullStr |
Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy |
title_full_unstemmed |
Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy |
title_sort |
self‐supply of o2 and h2o2 by a nanocatalytic medicine to enhance combined chemo/chemodynamic therapy |
publisher |
Wiley |
series |
Advanced Science |
issn |
2198-3844 |
publishDate |
2019-12-01 |
description |
Abstract Combined chemo/chemodynamic therapy is a promising strategy to achieve an improved anticancer effect. However, the hypoxic microenvironment and limited amount of H2O2 in most solid tumors severely restrict the efficacy of this treatment. Herein, the construction of a nanocatalytic medicine, CaO2@DOX@ZIF‐67, via a bottom‐up approach is described. CaO2@DOX@ZIF‐67 simultaneously supplies O2 and H2O2 to achieve improved chemo/chemodynamic therapy. In the weakly acidic environment within tumors, CaO2@DOX@ZIF‐67 is broken down to rapidly release the Fenton‐like catalyst Co2+ and the chemotherapy drug doxorubicin (DOX). The unprotected CaO2 reacts with H2O to generate both O2 and H2O2. The generated O2 relieves the hypoxia in the tumor and further improve the efficacy of DOX. Meanwhile, the generated H2O2 reacts with Co2+ ions to produce highly toxic •OH through a Fenton‐like reaction, resulting in improved chemodynamic therapy. |
topic |
CaO2 chemodynamic therapy chemotherapy doxorubicin ZIF‐67 |
url |
https://doi.org/10.1002/advs.201902137 |
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