Overexpression of an ALS-associated FUS mutation in C. elegans disrupts NMJ morphology and leads to defective neuromuscular transmission

Overexpression of an ALS-associated FUS mutation in C. elegans disrupts NMJ morphology and leads to defective neuromuscular transmission

The amyotrophic lateral sclerosis (ALS) neurodegenerative disorder has been associated with multiple genetic lesions, including mutations in the gene for fused in sarcoma (FUS), a nuclear-localized RNA/DNA-binding protein. Neuronal expression of the pathological form of FUS proteins in Caenorhabditi...

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Bibliographic Details
Main Authors: Sebastian M. Markert, Michael Skoruppa, Bin Yu, Ben Mulcahy, Mei Zhen, Shangbang Gao, Michael Sendtner, Christian Stigloher
Format: Article
Language:English
Published: The Company of Biologists 2020-12-01
Series:Biology Open
Subjects:
c. elegans
fused in sarcoma
amyotrophic lateral sclerosis
super-resolution array tomography
electron tomography
neuromuscular junction
Online Access:http://bio.biologists.org/content/9/12/bio055129

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