Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk - A Meta-Analysis

• Main Author: Yaping Zhao, Furu Wang, Shunlin Shan, Yiqi Zhao, Xueming Qiu, Xiangyang Li, Feng Jiao, Jianguo Wang, Yunxiang Du
• Format: Article
• Language: English
• Published: Ivyspring International Publisher 2010-01-01
• Series: International Journal of Medical Sciences
• Online Access: http://www.medsci.org/v07p0300.htm

<p>A number of studies have evaluated two functional polymorphisms on <i>p53</i> Arg72Pro and <i>GSTP1</i> Ile105Val, in relation to esophageal cancer susceptibility. However, the results remain conflicting rather than conclusive. This meta-analysis on 2919 cases and 4074 controls for <i>p53</i> Arg72Pro and 1885 cases and 2194 controls for <i>GSTP1</i> Ile105Val from 13 published case-control studies showed that no significant general main effects for <i>GSTP1</i> Ile105Val on esophageal cancer risk. However, we found that the <i>p53</i> Arg72Pro was associated with an increased risk of esophageal cancer ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.20, 95%CI=1.06-1.36) without any between-study heterogeneity.</p><p>In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with <i>p53</i> Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, <i>P</i>=0.09 for heterogeneity test), although we still failed to find any significant association between <i>GSTP1</i> Ile105Val polymorphism and esophageal cancer risk in different ethnicity. These results suggest that <i>p53</i> Arg72Pro polymorphism, but not <i>GSTP1</i> Ile105Val, may contribute to esophageal cancer development, especially in Asian. Additional well-designed large studies were required for the validation of this association.</p>