Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme

Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme

Inhibition of the β-carbonic anhydrase (CA, EC 4.2.1.1) from pathogenic Candida glabrata (CgNce103) by 1H-indole-2,3-dione 3-[N-(4-sulfamoylphenyl)thiosemicarbazones] 4a–m was investigated. All the compounds were found to be potent inhibitors of CgNce103, with inhibition constants in the range of 6....

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Bibliographic Details
Main Authors:	Atilla Akdemir, Andrea Angeli, Füsun Göktaş, Pınar Eraslan Elma, Nilgün Karalı, Claudiu T. Supuran
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2019-01-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:	sulfonamides candida glabrata carbonic anhydrase docking
Online Access:	http://dx.doi.org/10.1080/14756366.2018.1564045

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