An experimental model of Braak’s pretangle proposal for the origin of Alzheimer’s disease: the role of locus coeruleus in early symptom development

An experimental model of Braak’s pretangle proposal for the origin of Alzheimer’s disease: the role of locus coeruleus in early symptom development

Abstract Background The earliest brain pathology related to Alzheimer’s disease (AD) is hyperphosphorylated soluble tau in the noradrenergic locus coeruleus (LC) neurons. Braak characterizes five pretangle tau stages preceding AD tangles. Pretangles begin in young humans and persist in the LC while...

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Bibliographic Details
Main Authors:	Abhinaba Ghosh, Sarah E. Torraville, Bandhan Mukherjee, Susan G. Walling, Gerard M. Martin, Carolyn W. Harley, Qi Yuan
Format:	Article
Language:	English
Published:	BMC 2019-07-01
Series:	Alzheimer’s Research & Therapy
Subjects:	Locus coeruleus Norepinephrine Hyperphosphorylated tau Pretangles Odor discrimination Odor identification deficit
Online Access:	http://link.springer.com/article/10.1186/s13195-019-0511-2

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