Novel curcumin- and emodin-related compounds identified by <it>in silico </it>2D/3D conformer screening induce apoptosis in tumor cells
<p>Abstract</p> <p>Background</p> <p>Inhibition of the COP9 signalosome (CSN) associated kinases CK2 and PKD by curcumin causes stabilization of the tumor suppressor p53. It has been shown that curcumin induces tumor cell death and apoptosis. Curcumin and emodin block t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2005-08-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/5/97 |