Trauma-Induced Damage-Associated Molecular Patterns-Mediated Remote Organ Injury and Immunosuppression in the Acutely Ill Patient

Trauma is one of the leading causes of death and disability in the world. Multiple trauma or isolated traumatic brain injury are both indicative of human tissue damage. In the early phase after trauma, damage-associated molecular patterns (DAMPs) are released and give rise to sterile systemic inflam...

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Main Authors:	Mickael Vourc’h, Antoine Roquilly, Karim Asehnoune
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-06-01
Series:	Frontiers in Immunology
Subjects:	damage-associated molecular pattern posttraumatic immunosuppression remote organ dysfunction hospital-acquired infection critical care transfusion
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2018.01330/full

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spelling	doaj-758d8de07bc14c3d854c32d15bb5df8c2020-11-25T00:55:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-06-01910.3389/fimmu.2018.01330357023Trauma-Induced Damage-Associated Molecular Patterns-Mediated Remote Organ Injury and Immunosuppression in the Acutely Ill PatientMickael Vourc’h0Mickael Vourc’h1Antoine Roquilly2Antoine Roquilly3Karim Asehnoune4Karim Asehnoune5Laboratoire UPRES EA3826 “Thérapeutiques cliniques et expérimentales des infections”, IRS2 – Nantes Biotech, Université de Nantes, Nantes, FranceIntensive Care Unit, Anesthesia and Critical Care Department, Hôtel Dieu, University Hospital of Nantes, Nantes, FranceLaboratoire UPRES EA3826 “Thérapeutiques cliniques et expérimentales des infections”, IRS2 – Nantes Biotech, Université de Nantes, Nantes, FranceIntensive Care Unit, Anesthesia and Critical Care Department, Hôtel Dieu, University Hospital of Nantes, Nantes, FranceLaboratoire UPRES EA3826 “Thérapeutiques cliniques et expérimentales des infections”, IRS2 – Nantes Biotech, Université de Nantes, Nantes, FranceIntensive Care Unit, Anesthesia and Critical Care Department, Hôtel Dieu, University Hospital of Nantes, Nantes, FranceTrauma is one of the leading causes of death and disability in the world. Multiple trauma or isolated traumatic brain injury are both indicative of human tissue damage. In the early phase after trauma, damage-associated molecular patterns (DAMPs) are released and give rise to sterile systemic inflammatory response syndrome (SIRS) and organ failure. Later, protracted inflammation following sepsis will favor hospital-acquired infection and will worsen patient’s outcome through immunosuppression. Throughout medical care or surgical procedures, severe trauma patients will be subjected to endogenous or exogenous DAMPs. In this review, we summarize the current knowledge regarding DAMP-mediated SIRS or immunosuppression and the clinical consequences in terms of organ failure and infections.https://www.frontiersin.org/article/10.3389/fimmu.2018.01330/fulldamage-associated molecular patternposttraumatic immunosuppressionremote organ dysfunctionhospital-acquired infectioncritical caretransfusion
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mickael Vourc’h Mickael Vourc’h Antoine Roquilly Antoine Roquilly Karim Asehnoune Karim Asehnoune
spellingShingle	Mickael Vourc’h Mickael Vourc’h Antoine Roquilly Antoine Roquilly Karim Asehnoune Karim Asehnoune Trauma-Induced Damage-Associated Molecular Patterns-Mediated Remote Organ Injury and Immunosuppression in the Acutely Ill Patient Frontiers in Immunology damage-associated molecular pattern posttraumatic immunosuppression remote organ dysfunction hospital-acquired infection critical care transfusion
author_facet	Mickael Vourc’h Mickael Vourc’h Antoine Roquilly Antoine Roquilly Karim Asehnoune Karim Asehnoune
author_sort	Mickael Vourc’h
title	Trauma-Induced Damage-Associated Molecular Patterns-Mediated Remote Organ Injury and Immunosuppression in the Acutely Ill Patient
title_short	Trauma-Induced Damage-Associated Molecular Patterns-Mediated Remote Organ Injury and Immunosuppression in the Acutely Ill Patient
title_full	Trauma-Induced Damage-Associated Molecular Patterns-Mediated Remote Organ Injury and Immunosuppression in the Acutely Ill Patient
title_fullStr	Trauma-Induced Damage-Associated Molecular Patterns-Mediated Remote Organ Injury and Immunosuppression in the Acutely Ill Patient
title_full_unstemmed	Trauma-Induced Damage-Associated Molecular Patterns-Mediated Remote Organ Injury and Immunosuppression in the Acutely Ill Patient
title_sort	trauma-induced damage-associated molecular patterns-mediated remote organ injury and immunosuppression in the acutely ill patient
publisher	Frontiers Media S.A.
series	Frontiers in Immunology
issn	1664-3224
publishDate	2018-06-01
description	Trauma is one of the leading causes of death and disability in the world. Multiple trauma or isolated traumatic brain injury are both indicative of human tissue damage. In the early phase after trauma, damage-associated molecular patterns (DAMPs) are released and give rise to sterile systemic inflammatory response syndrome (SIRS) and organ failure. Later, protracted inflammation following sepsis will favor hospital-acquired infection and will worsen patient’s outcome through immunosuppression. Throughout medical care or surgical procedures, severe trauma patients will be subjected to endogenous or exogenous DAMPs. In this review, we summarize the current knowledge regarding DAMP-mediated SIRS or immunosuppression and the clinical consequences in terms of organ failure and infections.
topic	damage-associated molecular pattern posttraumatic immunosuppression remote organ dysfunction hospital-acquired infection critical care transfusion
url	https://www.frontiersin.org/article/10.3389/fimmu.2018.01330/full
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Trauma-Induced Damage-Associated Molecular Patterns-Mediated Remote Organ Injury and Immunosuppression in the Acutely Ill Patient

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