Design, synthesis, and biological evaluation of multiple targeting antimalarials

Design, synthesis, and biological evaluation of multiple targeting antimalarials

Malaria still threatens global health seriously today. While the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors, multi-targeting inhibitors are highly desired to overcome the increasingly serious drug resistance. Here, we performed a structure-bas...

Full description

Bibliographic Details
Main Authors: Yiqing Yang, Tongke Tang, Xiaolu Li, Thomas Michel, Liqin Ling, Zhenghui Huang, Maruthi Mulaka, Yue Wu, Hongying Gao, Liguo Wang, Jing Zhou, Brigitte Meunier, Hangjun Ke, Lubin Jiang, Yu Rao
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Drug design
Multiple targeting compounds
Antimalarial inhibitors
Mechanism of action
Membrane proteins
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352100174X

Internet

http://www.sciencedirect.com/science/article/pii/S221138352100174X

Similar Items