Effect of protamine sulfate on the isolated mesenteric arteries of normotensive and spontaneously hypertensive rats
We tested the relaxant effect of increased protamine sulfate (PS) amounts (10, 20, 50, 100 and 150 μg/ml) on the isolated mesenteric arteries of normotensive and spontaneously hypertensive (SH) rats, with or without endothelium. PS caused concentration-dependent relaxation of isolated mesenteric art...
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University of Belgrade, University of Novi Sad
2008-01-01
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| Series: | Archives of Biological Sciences |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2008/0354-46640802163O.pdf |
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doaj-758a764f509b45a2bfa29ea7574b6e7d2020-11-24T23:00:28ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46642008-01-0160216316810.2298/ABS0802163OEffect of protamine sulfate on the isolated mesenteric arteries of normotensive and spontaneously hypertensive ratsOreščanin-Dušić ZoranaMilovanović S.Spasić M.Radojičić R.Blagojević D.We tested the relaxant effect of increased protamine sulfate (PS) amounts (10, 20, 50, 100 and 150 μg/ml) on the isolated mesenteric arteries of normotensive and spontaneously hypertensive (SH) rats, with or without endothelium. PS caused concentration-dependent relaxation of isolated mesenteric arteries in both types of rats. The relaxation effect of PS was lower in SH rats than in normotensive ones. Our results indicate that the vascular smooth muscles play a significant role in PS-mediated relaxation. http://www.doiserbia.nb.rs/img/doi/0354-4664/2008/0354-46640802163O.pdfProtamine sulfatemesenteric arteryhypertensionvascular endotheliumrats |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Oreščanin-Dušić Zorana Milovanović S. Spasić M. Radojičić R. Blagojević D. |
| spellingShingle |
Oreščanin-Dušić Zorana Milovanović S. Spasić M. Radojičić R. Blagojević D. Effect of protamine sulfate on the isolated mesenteric arteries of normotensive and spontaneously hypertensive rats Archives of Biological Sciences Protamine sulfate mesenteric artery hypertension vascular endothelium rats |
| author_facet |
Oreščanin-Dušić Zorana Milovanović S. Spasić M. Radojičić R. Blagojević D. |
| author_sort |
Oreščanin-Dušić Zorana |
| title |
Effect of protamine sulfate on the isolated mesenteric arteries of normotensive and spontaneously hypertensive rats |
| title_short |
Effect of protamine sulfate on the isolated mesenteric arteries of normotensive and spontaneously hypertensive rats |
| title_full |
Effect of protamine sulfate on the isolated mesenteric arteries of normotensive and spontaneously hypertensive rats |
| title_fullStr |
Effect of protamine sulfate on the isolated mesenteric arteries of normotensive and spontaneously hypertensive rats |
| title_full_unstemmed |
Effect of protamine sulfate on the isolated mesenteric arteries of normotensive and spontaneously hypertensive rats |
| title_sort |
effect of protamine sulfate on the isolated mesenteric arteries of normotensive and spontaneously hypertensive rats |
| publisher |
University of Belgrade, University of Novi Sad |
| series |
Archives of Biological Sciences |
| issn |
0354-4664 |
| publishDate |
2008-01-01 |
| description |
We tested the relaxant effect of increased protamine sulfate (PS) amounts (10, 20, 50, 100 and 150 μg/ml) on the isolated mesenteric arteries of normotensive and spontaneously hypertensive (SH) rats, with or without endothelium. PS caused concentration-dependent relaxation of isolated mesenteric arteries in both types of rats. The relaxation effect of PS was lower in SH rats than in normotensive ones. Our results indicate that the vascular smooth muscles play a significant role in PS-mediated relaxation. |
| topic |
Protamine sulfate mesenteric artery hypertension vascular endothelium rats |
| url |
http://www.doiserbia.nb.rs/img/doi/0354-4664/2008/0354-46640802163O.pdf |
| work_keys_str_mv |
AT orescanindusiczorana effectofprotaminesulfateontheisolatedmesentericarteriesofnormotensiveandspontaneouslyhypertensiverats AT milovanovics effectofprotaminesulfateontheisolatedmesentericarteriesofnormotensiveandspontaneouslyhypertensiverats AT spasicm effectofprotaminesulfateontheisolatedmesentericarteriesofnormotensiveandspontaneouslyhypertensiverats AT radojicicr effectofprotaminesulfateontheisolatedmesentericarteriesofnormotensiveandspontaneouslyhypertensiverats AT blagojevicd effectofprotaminesulfateontheisolatedmesentericarteriesofnormotensiveandspontaneouslyhypertensiverats |
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