The Crystal Structure of Thermotoga maritima Class III Ribonucleotide Reductase Lacks a Radical Cysteine Pre-Positioned in the Active Site.

The Crystal Structure of Thermotoga maritima Class III Ribonucleotide Reductase Lacks a Radical Cysteine Pre-Positioned in the Active Site.

Ribonucleotide reductases (RNRs) catalyze the reduction of ribonucleotides to deoxyribonucleotides, the building blocks for DNA synthesis, and are found in all but a few organisms. RNRs use radical chemistry to catalyze the reduction reaction. Despite RNR having evolved several mechanisms for genera...

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Bibliographic Details
Main Authors: Oskar Aurelius, Renzo Johansson, Viktoria Bågenholm, Daniel Lundin, Fredrik Tholander, Alexander Balhuizen, Tobias Beck, Margareta Sahlin, Britt-Marie Sjöberg, Etienne Mulliez, Derek T Logan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4493059?pdf=render

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http://europepmc.org/articles/PMC4493059?pdf=render

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