TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP

TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP

cFLIP is required for epidermal integrity and skin inflammation silencing via protection from TNF-induced keratinocyte apoptosis. Here, we generated and analyzed cFLIP epidermal KO mice with additional TNF deficiency. Intriguingly, the ablation of TNF rescued the pathological phenotype of epidermal...

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Bibliographic Details
Main Authors: Maria Feoktistova, Roman Makarov, Martin Leverkus, Amir S. Yazdi, Diana Panayotova-Dimitrova
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
keratinocytes
cell death
inflammation
cFLIP
TNF
skin
Online Access:https://www.mdpi.com/1422-0067/21/22/8859

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