The <it>GATA1s</it> isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress <it>MYB, CCND2</it> and <it>SKI</it> during erythroid differentiation of K562 cells

The <it>GATA1s</it> isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress <it>MYB, CCND2</it> and <it>SKI</it> during erythroid differentiation of K562 cells

<p>Abstract</p> <p>Background</p> <p>Although <it>GATA1</it> is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms <it>GATA1s</it&g...

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Bibliographic Details
Main Authors: Halsey Christina, Docherty Marie, McNeill Mhairi, Gilchrist Derek, Le Brocq Michelle, Gibson Brenda, Graham Gerard
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Journal of Hematology & Oncology
Subjects:
GATA1 transcription factor
Humans
Down syndrome/*genetics/physiopathology
Leukaemia
Megakaryoblastic
Acute/genetics
Dendritic cells
Cell differentiation/*drug effects
Online Access:http://www.jhoonline.org/content/5/1/45

Internet

http://www.jhoonline.org/content/5/1/45

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