CREB targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin.

CREB targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin.

The RNA-binding protein Tristetraprolin (TTP, ZFP36) functions as a tumor suppressor that impairs the development and disables the maintenance of MYC-driven lymphoma. In addition, other human cancers expressed reduced levels of TTP, suggesting that it may function as a tumor suppressor in several ma...

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Bibliographic Details
Main Authors: Mohammad Fallahi, Antonio L Amelio, John L Cleveland, Robert J Rounbehler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4277357?pdf=render

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