Interleukin-1β and interleukin-6 increase levels of apolipoprotein B mRNA and decrease accumulation of its protein in culture medium of HepG2 cells

Interleukin-1β and interleukin-6 increase levels of apolipoprotein B mRNA and decrease accumulation of its protein in culture medium of HepG2 cells

The purpose of the present study was to examine the regulation of levels of apolipoprotein B (apoB) mRNA and its protein by cytokines in HepG2 cells. A dose-dependent increase in apoB mRNA levels was observed in the presence of either interleukin-1β (IL-1β) or IL-6 alone. This increase occurred as e...

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Bibliographic Details
Main Authors:	Keiko Yokoyama, Toshiyuki Ishibashi, Liang Yi-qiang, Akira Nagayoshi, Tamio Teramoto, Yukio Maruyama
Format:	Article
Language:	English
Published:	Elsevier 1998-01-01
Series:	Journal of Lipid Research
Subjects:	cytokine Northern blot analysis intracellular degradation LDL receptor
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520342073

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