Nonheritable cellular variability accelerates the evolutionary processes of cancer.

Nonheritable cellular variability accelerates the evolutionary processes of cancer.

Recent cancer studies emphasize that genetic and heritable epigenetic changes drive the evolutionary rate of cancer progression and drug resistance. We discuss the ways in which nonheritable aspects of cellular variability may significantly increase evolutionary rate. Nonheritable variability arises...

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Main Authors: Steven A Frank, Marsha Rich Rosner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3317895?pdf=render
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spelling doaj-755e1d921ed44b6495a5602fef31f07b2021-07-02T07:44:46ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852012-01-01104e100129610.1371/journal.pbio.1001296Nonheritable cellular variability accelerates the evolutionary processes of cancer.Steven A FrankMarsha Rich RosnerRecent cancer studies emphasize that genetic and heritable epigenetic changes drive the evolutionary rate of cancer progression and drug resistance. We discuss the ways in which nonheritable aspects of cellular variability may significantly increase evolutionary rate. Nonheritable variability arises by stochastic fluctuations in cells and by physiological responses of cells to the environment. New approaches to drug design may be required to control nonheritable variability and the evolution of resistance to chemotherapy.http://europepmc.org/articles/PMC3317895?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Steven A Frank
Marsha Rich Rosner
spellingShingle Steven A Frank
Marsha Rich Rosner
Nonheritable cellular variability accelerates the evolutionary processes of cancer.
PLoS Biology
author_facet Steven A Frank
Marsha Rich Rosner
author_sort Steven A Frank
title Nonheritable cellular variability accelerates the evolutionary processes of cancer.
title_short Nonheritable cellular variability accelerates the evolutionary processes of cancer.
title_full Nonheritable cellular variability accelerates the evolutionary processes of cancer.
title_fullStr Nonheritable cellular variability accelerates the evolutionary processes of cancer.
title_full_unstemmed Nonheritable cellular variability accelerates the evolutionary processes of cancer.
title_sort nonheritable cellular variability accelerates the evolutionary processes of cancer.
publisher Public Library of Science (PLoS)
series PLoS Biology
issn 1544-9173
1545-7885
publishDate 2012-01-01
description Recent cancer studies emphasize that genetic and heritable epigenetic changes drive the evolutionary rate of cancer progression and drug resistance. We discuss the ways in which nonheritable aspects of cellular variability may significantly increase evolutionary rate. Nonheritable variability arises by stochastic fluctuations in cells and by physiological responses of cells to the environment. New approaches to drug design may be required to control nonheritable variability and the evolution of resistance to chemotherapy.
url http://europepmc.org/articles/PMC3317895?pdf=render
work_keys_str_mv AT stevenafrank nonheritablecellularvariabilityacceleratestheevolutionaryprocessesofcancer
AT marsharichrosner nonheritablecellularvariabilityacceleratestheevolutionaryprocessesofcancer
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