Nafamostat Mesilate Induces Production of Interleukin-12 and -18 in Human Peripheral Blood Mononuclear Cells

Nafamostat Mesilate Induces Production of Interleukin-12 and -18 in Human Peripheral Blood Mononuclear Cells

Little has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-α and interferon-γ production, and the expression of intercellular adhesion molecules-1, B7.1, B7....

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Main Authors: Goutarou Katsuno, Hideo K. Takahashi, Hiromi Iwagaki, Kenji Mizuno, Shuji Mori, Tadashi Yoshino, Masahiro Nishibori, Noriaki Tanaka
Format: Article
Language:English
Published: Elsevier 2005-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319321644
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spelling doaj-754bad3214e94fff807e56daacf5946a2020-11-25T02:31:28ZengElsevierJournal of Pharmacological Sciences1347-86132005-01-01984463466Nafamostat Mesilate Induces Production of Interleukin-12 and -18 in Human Peripheral Blood Mononuclear CellsGoutarou Katsuno0Hideo K. Takahashi1Hiromi Iwagaki2Kenji Mizuno3Shuji Mori4Tadashi Yoshino5Masahiro Nishibori6Noriaki Tanaka7Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, 2-5-1 Shikata-cho, Okayama 700-8558, JapanDepartment of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, 2-5-1 Shikata-cho, Okayama 700-8558, Japan; Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, 2-5-1 Shikata-cho, Okayama 700-8558, JapanDepartment of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, 2-5-1 Shikata-cho, Okayama 700-8558, JapanDepartment of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, 2-5-1 Shikata-cho, Okayama 700-8558, JapanDepartment of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, 2-5-1 Shikata-cho, Okayama 700-8558, JapanDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, 2-5-1 Shikata-cho, Okayama 700-8558, JapanDepartment of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, 2-5-1 Shikata-cho, Okayama 700-8558, Japan; Corresponding author. FAX: +81-86-235-7140 E-mail: mbori@md.okayama-u.ac.jpDepartment of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, 2-5-1 Shikata-cho, Okayama 700-8558, JapanLittle has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-α and interferon-γ production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. The cytokine production and adhesion molecule expression were abolished by anti-IL-12 and IL-18 antibodies. Therefore, IL-18 and IL-12 may play roles in the significant and immediate effects of nafamostat mesilate. Keywords:: nafamostat mesilate, interleukin-18, interleukin-12http://www.sciencedirect.com/science/article/pii/S1347861319321644
collection DOAJ
language English
format Article
sources DOAJ
author Goutarou Katsuno
Hideo K. Takahashi
Hiromi Iwagaki
Kenji Mizuno
Shuji Mori
Tadashi Yoshino
Masahiro Nishibori
Noriaki Tanaka
spellingShingle Goutarou Katsuno
Hideo K. Takahashi
Hiromi Iwagaki
Kenji Mizuno
Shuji Mori
Tadashi Yoshino
Masahiro Nishibori
Noriaki Tanaka
Nafamostat Mesilate Induces Production of Interleukin-12 and -18 in Human Peripheral Blood Mononuclear Cells
Journal of Pharmacological Sciences
author_facet Goutarou Katsuno
Hideo K. Takahashi
Hiromi Iwagaki
Kenji Mizuno
Shuji Mori
Tadashi Yoshino
Masahiro Nishibori
Noriaki Tanaka
author_sort Goutarou Katsuno
title Nafamostat Mesilate Induces Production of Interleukin-12 and -18 in Human Peripheral Blood Mononuclear Cells
title_short Nafamostat Mesilate Induces Production of Interleukin-12 and -18 in Human Peripheral Blood Mononuclear Cells
title_full Nafamostat Mesilate Induces Production of Interleukin-12 and -18 in Human Peripheral Blood Mononuclear Cells
title_fullStr Nafamostat Mesilate Induces Production of Interleukin-12 and -18 in Human Peripheral Blood Mononuclear Cells
title_full_unstemmed Nafamostat Mesilate Induces Production of Interleukin-12 and -18 in Human Peripheral Blood Mononuclear Cells
title_sort nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2005-01-01
description Little has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-α and interferon-γ production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. The cytokine production and adhesion molecule expression were abolished by anti-IL-12 and IL-18 antibodies. Therefore, IL-18 and IL-12 may play roles in the significant and immediate effects of nafamostat mesilate. Keywords:: nafamostat mesilate, interleukin-18, interleukin-12
url http://www.sciencedirect.com/science/article/pii/S1347861319321644
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