Schisandrin Protects against Norepinephrine-Induced Myocardial Hypertrophic Injury by Inhibiting the JAK2/STAT3 Signaling Pathway

Schisandrin Protects against Norepinephrine-Induced Myocardial Hypertrophic Injury by Inhibiting the JAK2/STAT3 Signaling Pathway

Aims. Heart failure is closely associated with norepinephrine-(NE-) induced cardiomyocyte hypertrophy. Schisandrin is derived from the traditional Chinese medicine Schisandra; it has a variety of pharmacological activities, and the mechanism of schisandrin-mediated protection of the cardiovascular s...

Full description

Bibliographic Details
Main Authors:	Min Yang, Xing-Can Jiang, Lei Wang, Dong-An Cui, Jing-Yan Zhang, Xu-Rong Wang, Hai-Peng Feng, Kang Zhang, Kai Zhang, Jian-Xi Li, Xue-Zhi Wang
Format:	Article
Language:	English
Published:	Hindawi Limited 2021-01-01
Series:	Evidence-Based Complementary and Alternative Medicine
Online Access:	http://dx.doi.org/10.1155/2021/8129512

Similar Items

A Simple and Convenient Method for Simultaneous Determination of Schizandrol A, Schizandrol B, Schisandrin A, γ-Schisandrin, and Schisandrin C
by: Yu Zhou, et al.
Published: (2016-01-01)

Beneficial effects of schisandrin B on the cardiac function in mice model of myocardial infarction.
by: Pengsheng Chen, et al.
Published: (2013-01-01)

Schisandrin B for the treatment of male infertility
by: Di‐Xin Zou, et al.
Published: (2021-02-01)

JAK/STAT signalling
by: Is'Harc, Hayaatun
Published: (2002)

Clinicopathologic and prognostic significance of VEGF, JAK2 and STAT3 in patients with nasopharyngeal carcinoma
by: Jin-Zhang Cheng, et al.
Published: (2018-08-01)

Feifukang ameliorates pulmonary fibrosis by inhibiting JAK-STAT signaling pathway
by: Hongbo Li, et al.
Published: (2018-08-01)

Protein Inhibitor of Activated STAT (PIAS) Negatively Regulates the JAK/STAT Pathway by Inhibiting STAT Phosphorylation and Translocation
by: Guo-Juan Niu, et al.
Published: (2018-10-01)

Therapeutic effect of Schisandrin A on avian colibacillosis through gut-liver axis
by: Jialu Bao, et al.
Published: (2021-10-01)

JAK-STAT signalling at chromatin
by: Dawson, M. A. F.
Published: (2010)

The role of JAKs and STATs in chemoresistance
by: Carmo, Catarina Ramos do
Published: (2010)

Research Advances of JAK/STAT Signaling Pathway in Lung Cancer
by: Xin YANG, et al.
Published: (2019-01-01)

Effect of MiR-210 on the Chemosensitivity of Breast Cancer by Regulating JAK-STAT Signaling Pathway
by: Zeyu Xing, et al.
Published: (2021-01-01)

Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss
by: Jia Wang, et al.
Published: (2020-07-01)

Dihydrotanshinone Inhibits Hepatocellular Carcinoma by Suppressing the JAK2/STAT3 Pathway
by: Xue Hu, et al.
Published: (2021-04-01)

JAK-STAT Signalling Pathway in Cancer
by: Andrew J. Brooks, et al.
Published: (2020-07-01)

JAK/STAT-deficient cell lines
by: C.A. Bonjardim
Published: (1998-11-01)

Signal transduction through JAKS and STATS
by: Lillemeier, Bjorn Freimut
Published: (2001)

Specificity in JAK/STAT signal transduction
by: Broughton, Nicola Ann
Published: (1998)

Endocytic regulation of JAK/STAT signalling
by: Vogt, Katja L.
Published: (2014)

Regulation of JAK/STAT signalling by endocytosis
by: Moore, Rachel
Published: (2018)

JAK-STAT in Early Hematopoiesis and Leukemia
by: Eirini Sofia Fasouli, et al.
Published: (2021-05-01)

Fructose 1,6-diphosphate alleviates myocardial ischemia reperfusion injury in rats through JAK2/STAT3 pathway
by: Ju-Fei Wang, et al.
Published: (2018-01-01)

The Effect of Schisandrin B on the Development of Multiple Sclerosis
by: Mustafa Cakir, et al.
Published: (2019-12-01)

Composition of Schizandra chinensis Baill—An Approach of Radioprotective Effects of Schisandrin B
by: Ming - Chih Wang, et al.
Published: (2008)

Progenitor expansion in <it>apc </it>mutants is mediated by Jak/Stat signaling
by: Lin Junji, et al.
Published: (2011-12-01)

JAK/STAT Pathway Mutations in T-ALL, Including the STAT5B N642H Mutation, are Sensitive to JAK1/JAK3 Inhibitors
by: Inge Govaerts, et al.
Published: (2019-12-01)

Postconditioning inhibits myocardial apoptosis during prolonged reperfusion via a JAK2-STAT3-Bcl-2 pathway
by: Liang Degang, et al.
Published: (2011-08-01)

Inactivation Of Type I IFN Jak-STAT Pathway In EBV Latency
by: Ning, Shunbin, et al.
Published: (2016)

Differential Action between Schisandrin A and Schisandrin B in Eliciting an Anti-Inflammatory Action: The Depletion of Reduced Glutathione and the Induction of an Antioxidant Response.
by: Pou Kuan Leong, et al.
Published: (2016-01-01)

Modulation of norepinephrine release by endogenous mediators in myocardial ischemia
by: Mackins, Christina J.
Published: (2006)

Granulocyte colony-stimulating factor attenuates myocardial remodeling and ventricular arrhythmia susceptibility via the JAK2-STAT3 pathway in a rabbit model of coronary microembolization
by: Weiwei Wang, et al.
Published: (2020-02-01)

JAK-STAT Domain Enhanced MUC1-CAR-T Cells Induced Esophageal Cancer Elimination
by: Zhang H, et al.
Published: (2020-10-01)

The JAK/STAT Pathway in Skeletal Muscle Pathophysiology
by: Viviana Moresi, et al.
Published: (2019-04-01)

Methotrexate Is a JAK/STAT Pathway Inhibitor.
by: Sally Thomas, et al.
Published: (2015-01-01)

JAK-STAT pathway in the control of mycobacterial infections
by: Pean, Claire
Published: (2013)

Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway
by: Qianqian Yin, et al.
Published: (2021-09-01)

Icaritin inhibits JAK/STAT3 signaling and growth of renal cell carcinoma.
by: Shasha Li, et al.
Published: (2013-01-01)

Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland
by: Min Tian, et al.
Published: (2020-11-01)

C/EBPβ regulates the JAK/STAT signaling pathway in triple‐negative breast cancer
by: Shu Wang, et al.
Published: (2021-04-01)

Interferon functional analog activates antiviral Jak/Stat signaling through integrin in an arthropod
by: Jie Gao, et al.
Published: (2021-09-01)