Synergy of NUP98-HOXA10 Fusion Gene and NrasG12D Mutation Preserves the Stemness of Hematopoietic Stem Cells on Culture Condition

Synergy of NUP98-HOXA10 Fusion Gene and NrasG12D Mutation Preserves the Stemness of Hematopoietic Stem Cells on Culture Condition

Natural hematopoietic stem cells (HSC) are susceptible and tend to lose stemness, differentiate, or die on culture condition in vitro, which adds technical challenge for maintaining <i>bona fide</i> HSC-like cells, if ever generated, in protocol screening from pluripotent stem cells. It...

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Bibliographic Details
Main Authors: Yong Dong, Chengxiang Xia, Qitong Weng, Tongjie Wang, Fangxiao Hu, Kaitao Wang, Xiaofei Liu, Yang Geng, Lijuan Liu, Hongling Wu, Juan Du
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
NUP98-HOXA10HD
NrasG12D
hematopoietic stem cells
Online Access:https://www.mdpi.com/2073-4409/8/9/951

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https://www.mdpi.com/2073-4409/8/9/951

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